The mast cell demystified: A novel target for anti-inflammatory strategies after circulatory arrest?

Balsam, Leora B.; DeAnda, Abelardo

doi:10.1016/j.jtcvs.2016.06.026

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MCs protect from the exacerbated allergic skin inflammation induced by repeated allergen challenges [89]. MCs were also utilized as an alternative target in the vasoplegic response in cardiac surgery [90], while MC protease 7 could promote angiogenesis by the degradation of integrin subunits [91].…”

Section: Diabetic Foot Ulcerationmentioning

confidence: 99%

Mast Cells in Diabetes and Diabetic Wound Healing

et al. 2020

View full text Add to dashboard Cite

Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in connective tissues. Apart from their classical role in allergies, MCs also mediate various inflammatory responses due to the nature of their secretory products. They are involved in important physiological and pathophysiological responses related to inflammation, chronic wounds, and autoimmune diseases. There are also indications that MCs are associated with diabetes and its complications. MCs and MC-derived mediators participate in all wound healing stages and are involved in the pathogenesis of non-healing, chronic diabetic foot ulcers (DFUs). More specifically, recent work has shown increased degranulation of skin MCs in human diabetes and diabetic mice, which is associated with impaired wound healing. Furthermore, MC stabilization, either systemic or local at the skin level, improves wound healing in diabetic mice. Understanding the precise role of MCs in wound progression and healing processes can be of critical importance as it can lead to the development of new targeted therapies for diabetic foot ulceration, one of the most devastating complications of diabetes.

show abstract

Section: Diabetic Foot Ulcerationmentioning

confidence: 99%