The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Edwards, Alan M.

doi:10.1111/j.1365-2222.2008.03000.x

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…SCFAs can reduce the level of intestinal inflammation, thereby protecting the intestinal barrier [ 39 ]. SCFAs can inhibit histone deacetylase (HDAC) and G protein coupled receptor (GPCR), while GPCRs are involved in lung diseases [ 40 ]. Compared with the irradiated group, the therapeutic administration of PC significantly increased the relative abundance of Faecalibacterium , Lachnoclostridium , Ruminiclostridium , and Clostridiales , increased the synthesis of SCFAs, and enhanced its inhibitory effect on HDACs and GPCRs.…”

Section: Discussionmentioning

confidence: 99%

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model

Li¹,

Lu²,

Liu³

et al. 2020

Biomedicine & Pharmacotherapy

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Objective Radiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina , has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied. Design X-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-α, and IL-6 at different time after irradiation were evaluated. Results Phycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. Conclusion Phycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis.

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Section: Discussionmentioning

confidence: 99%

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model

Li¹,

Lu²,

Liu³

et al. 2020

Biomedicine & Pharmacotherapy

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show abstract

“…They also participate in a variety of pathological processes such as asthma and allergy (Beaven, 2009; Edwards, 2008). Given that mast cells have the ability to produce and release several inflammatory products including cytokines, chemokines and eicosanoids, mast cells and their derived mediators have been recognized as a potential target for therapeutic intervention.…”

Section: Discussionmentioning

confidence: 99%

Characterization and modulation of canine mast cell derived eicosanoids

Lin

London

2010

Veterinary Immunology and Immunopathology

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Mast cells play an important role in both innate and acquired immunity as well as several pathological conditions including allergy, arthritis and neoplasia. They influence these processes by producing a variety of mediators including cytokines, chemokines and eicosanoids. Very little is currently known about the spectrum of inflammatory mediators, particularly eicosanoids (prostaglandins and leukotrienes), produced by canine mast cells. This is important since modulating mast cell derived eicosanoids may help in the treatment of autoimmune and inflammatory disorders. The purpose of this study was to investigate the spectrum of eicosanoids produced by normal canine mast cells and to evaluate the effects of cytokines and non-steroidal anti-inflammatory mediators (NSAIDS) on eicosanoid production and release. Canine bone marrow derived cultured mast cells (cBMCMCs) expressed COX-1, COX-2, and 5-LOX and synthesized and released PGD2, PGE2, LTB4, and LTC4 following activation by a variety of stimuli. The selective COX-2 NSAIDs carprofen (Rimadyl®) and deracoxib (Deramaxx®) inhibited PGD2 and PGE2 production but only slightly inhibited LTB4 and LTC4. The mixed COX-1/COX-2 inhibitor piroxicam blocked PGD2 and PGE2 production, but upregulated LTC4 following treatment while tepoxilan (Zubrin®), a pan COX/LOX inhibitor, markedly reduced the production of all eicosanoids. The LOX inhibitor nordihydroguaiaretic acid (NDGA) prevented LTB4/LTC4 release and BMBMC degranulation. Pre-incubation of cBMCMCs with IL-4 and SCF sensitized these cells to degranulation in response to substance P. In conclusion, canine BMCMCs produce an array of eicosanoids similar to those produced by mast cells from other species. Tepoxilan appeared to be the most effective NSAID for blocking eicosanoid production and thus may be useful for modulating mast cell mediated responses in dogs.

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“…In a study on the effects of MWCNT administration on pulmonary function, pulmonary exposure to MWCNTs induced inflammatory signaling marked by the production of IL‐33, protease (MMP13), and chemokines (CCL3 and CCL11), which collectively promoted inflammatory and fibrotic changes within the lung (Uchida et al, 2017; Wang, Xia, et al, 2011). For a long time, mast cells have been known to play an important role in diseases such as asthma, AD, allergic rhinitis, and anaphylaxis (Edwards, 2008). Increasing evidence suggests that mast cells may be recruited after ENM exposure and can contribute significantly to ENM immunotoxicity (Smith et al, 2014).…”

Section: The Immunotoxicity and Nanotoxicity Of Enms Targeting The Il...mentioning

confidence: 99%

The importance of the IL‐1 family of cytokines in nanoimmunosafety and nanotoxicology

Zhang

Luo

Yang

et al. 2022

WIREs Nanomed Nanobiotechnol

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Engineered nanomaterials (ENMs) to which humans are exposed intentionally as nanomedicines or unintentionally as invaders, may elicit unforeseen immune reactions. An uncontrollable ENM‐induced immune response poses a potential danger to the human body. During an immunological reaction, interleukin (IL)‐1 family cytokines, which play key roles under both physiological and pathological conditions, can be secreted by various types of cells into the surrounding environment to induce a series of defensive reactions. However, the crucial roles played by IL‐1 family cytokines in ENM‐induced immunological responses have not attracted enough attention from researchers to date. In this review, ENM‐mediated inflammatory responses and immunotoxicity are discussed, with the main focus directed to IL‐1 family cytokines, including IL‐1α, IL‐1β, IL‐1Ra, IL‐18, IL‐33, IL‐36, IL‐37, and IL‐38. The potential molecular mechanisms of IL‐1 family cytokine activity triggered by ENMs, particularly the activation of IL‐1α, IL‐1β, IL‐18, and IL‐33, are also reviewed. The understanding of IL‐1 family cytokines on nanoimmunosafety provides a fundamental basis for designing safe ENMs that can potentially be used for nanomedicine.This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Cited by 8 publications

References 16 publications

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model

Characterization and modulation of canine mast cell derived eicosanoids

The importance of the IL‐1 family of cytokines in nanoimmunosafety and nanotoxicology

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