The Marsupialization Operation for Pilonidal Sinus

Lawrence, Knowles B.; Baker, William J.

doi:10.1056/nejm195107262450403

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…Data on recurrence and follow-up times in primary open PSD treatment pertaining to 21,583 patients were extracted from 205 additional non-RCTs 4 , 60 , 74 , 75 , 111 , 112 , 114 , 115 , 117 , 118 , 121 – 126 , 128 – 134 , 136 , 137 , 141 , 143 , 149 , 153 – 156 , 160 , 161 , 163 , 167 – 171 , 174 , 175 , 177 , 181 , 182 , 188 – 192 , 194 , 196 , 197 , 199 – 201 , 203 , 206 , 208 , 215 , 216 , 218 , 220 , 221 , 223 , 224 , 230 , 233 , 237 – 373 . Among these patients, a recurrence of 3.4% (95% CI 3.1–3.6%) was observed in patients at 12 months, 7.0% (95% CI 6.5–7.4%) at 24 months, 16.8% (95% CI 15.8–17.8%) at 60 months, 32.0% (95% CI 29.6–34.4%) at 120 months, and 67.9% (95% CI 53.3–82.4%) at 240 months (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Data on recurrence and follow-up times pertaining to 3,207 patients treated for PSD by other flap techniques were extracted from 55 additional non-RCTs 4 , 108 , 109 , 115 , 129 , 132 , 133 , 137 , 143 , 163 , 170 , 171 , 177 , 188 , 190 , 193 , 200 , 204 , 215 , 218 , 224 , 230 , 245 , 272 , 279 , 294 , 303 , 313 , 315 , 317 , 318 , 336 , 352 , 358 , 363 , 369 , 593 , 605 – 622 . Among these patients, a recurrence of 1.8% (95% CI 1.2–2.3%) was observed in patients at 12 months, 5.6% (95% CI 4.5–6.7%) at 24 months, 9.4% (95% CI 7.6–11.1%) at 60 months, and 16.3% (95% CI 11.8–20.9%) at 120 months (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

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Common surgical procedures in pilonidal sinus disease: A meta-analysis, merged data analysis, and comprehensive study on recurrence

Stauffer

Luedi

Kauf

et al. 2018

Sci Rep

192

191

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We systematically searched available databases. We reviewed 6,143 studies published from 1833 to 2017. Reports in English, French, German, Italian, and Spanish were considered, as were publications in other languages if definitive treatment and recurrence at specific follow-up times were described in an English abstract. We assessed data in the manner of a meta-analysis of RCTs; further we assessed non-RCTs in the manner of a merged data analysis. In the RCT analysis including 11,730 patients, Limberg & Dufourmentel operations were associated with low recurrence of 0.6% (95%CI 0.3–0.9%) 12 months and 1.8% (95%CI 1.1–2.4%) respectively 24 months postoperatively. Analysing 89,583 patients from RCTs and non-RCTs, the Karydakis & Bascom approaches were associated with recurrence of only 0.2% (95%CI 0.1–0.3%) 12 months and 0.6% (95%CI 0.5–0.8%) 24 months postoperatively. Primary midline closure exhibited long-term recurrence up to 67.9% (95%CI 53.3–82.4%) 240 months post-surgery. For most procedures, only a few RCTs without long term follow up data exist, but substitute data from numerous non-RCTs are available. Recurrence in PSD is highly dependent on surgical procedure and by follow-up time; both must be considered when drawing conclusions regarding the efficacy of a procedure.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Common surgical procedures in pilonidal sinus disease: A meta-analysis, merged data analysis, and comprehensive study on recurrence

Stauffer

Luedi

Kauf

et al. 2018

Sci Rep

192

191

View full text Add to dashboard Cite

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“…The nature of the binding of penicillin to the proteins is unknown. Binding as a thioester has recently been favoured over earlier suggestions of an amide or ester linkage because of the release of bound penicillin under conditions where the former, but not the latter, would be cleaved [28]. The finding that release is enzymic [6] and does not occur with neutral hydroxylamine (or 2-mercaptoethanol) if the proteins are denatured by heat or anionic detergents decreases the strength of this argument.…”

Section: Discussionmentioning

confidence: 99%

Properties of the Penicillin‐Binding Proteins of Escherichia coli K12

Spratt

1977

European Journal of Biochemistry

652

541

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Benzyl[14C] penicillin binds to six proteins with molecular weights of between 40000 and 91000 in the inner membrane of Escherichia coli. Two additional binding proteins with molecular weights of 29000 and 32000 were sometimes detected. All proteins were accessible to benzyl[14C]penicillin in whole cells. Proteins 5 and 6 released bound benzyl[14C]penicillin with half times of 5 and 19 min at 30 °C but the other binding proteins showed less than 50% release during a 60‐min period at 30 °C. The rate of release of bound penicillin from some of the proteins was greatly stimulated by 2‐mercaptoethanol and neutral hydroxylamine. Release of benzyl[14C]penicillin did not occur if the binding proteins were denatured in anionic detergent and so was probably enzymic. No additional binding proteins were detected with two [14C]cephalosporins. These β‐lactams bound to either all or some of those proteins to which benzyl[14C]penicillin bound. No binding proteins have been detected in the outer membrane of E. coli with any β‐[14C]lactam. The binding of a range of unlabelled penicillins and cephalosporins were studied by measuring their competition for the binding of benzyl[14C]penicillin to the six penicillin‐binding proteins. These results, together with those obtained by direct binding experiments with β‐[14C]lactams, showed that penicillins bind to all six proteins but that at least some cephalosporins fail to bind, or bind very slowly, to proteins 2, 5 and 6, although they bind to the other proteins. Since these cephalosporins inhibited cell division and caused cell lysis at concentrations where we could detect no binding to proteins 2, 5 and 6, we believe that these latter proteins are not the targets at which β‐lactams bind to elicit the above physiological responses. The binding properties of proteins 1, 3 and 4 correlate reasonably well with those expected for the above killing targets.

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“…In a series of 359 cases using this technique, in the majority of them Lawrence & Baker (1951) laid open the sinus in its full length with an incision as midline as possible. Other lateral sinuses or tracts were treated similarly.…”

Section: Treatmentmentioning

confidence: 99%