The mARS complex: a critical mediator of immune regulation and homeostasis
Sharon Bright Amanya,
Damilola Oyewole-Said,
Keenan J. Ernste
et al.
Abstract:Over the course of evolution, many proteins have undergone adaptive structural changes to meet the increasing homeostatic regulatory demands of multicellularity. Aminoacyl tRNA synthetases (aaRS), enzymes that catalyze the attachment of each amino acid to its cognate tRNA, are such proteins that have acquired new domains and motifs that enable non-canonical functions. Through these new domains and motifs, aaRS can assemble into large, multi-subunit complexes that enhance the efficiency of many biological funct… Show more
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