The Marine Ecosystem as a Source of Antibiotics

López, Yuly; Cepas, Virginio; Soto, Sara M.

doi:10.1007/978-3-319-69075-9_1

Cited by 10 publications

(8 citation statements)

References 139 publications

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“…Different studies have shown the frequency of scrutable antimicrobial activity in marine molluscs. So, according to the mentioned results, it can be concluded that cephalopods are a source in the discovery of new substances to the development of drugs especially new types of antibiotics which have a better efficiency than the synthetic antibiotics (46)(47)(48)(49)(50). Generally, there are a few studies on the antimicrobial activities of internal bone of cephalopods.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus

Yazdanpanah

Javid

Honarmandrad

et al. 2021

Environ Health Eng Manag

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Background: The presence of medicines in the environment is considered as a serious threat to the human health. The entrance of these substances into the water sources causes soil pollution, which eventually leads to the environmental pollution and it creates some problems for the public health. Also, increasing antibiotic resistant bacteria has attracted the attention of researchers to the use of natural resources such as marine products, for producing new antibiotics. The aim of this study was to evaluate antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus. Methods: At first, cuttlebones were washed, dried, and powdered. Then, the powdered cuttlebone was characterized. In the next step, its antimicrobial activities were evaluated using agar well diffusion technique, and minimum inhibitory concentration (MIC) was calculated. Results: The powdered cuttlebone was found to be effective against K. oxytoca (24 mm, MIC: 10-1 mg/mL), but no antimicrobial response was found against S. aureus. Also, the powdered cuttlebone antifungal activity and MIC against A. flavus were recorded 23 mm and 10-1 mg/mL, respectively. Conclusion: The obtained results suggest antimicrobial activities of powdered cuttlebone, which are concentration dependent. Furthermore, cuttlebone can be used as an accessible natural source to provide novel, low cost, and safe antimicrobial agents.

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Section: Discussionmentioning

confidence: 99%

Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus

Yazdanpanah

Javid

Honarmandrad

et al. 2021

Environ Health Eng Manag

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“…PTs are the most effective agents for fighting bacterial biofilms because they penetrate the bacterial cell wall by changing the shape of the cell membrane and causing cell death [87,88]. Bacterial cell wall permeability is damaged by PTs, which cause proton leakage in the cell membrane, thus structural changes in the nuclear membrane leading to bacterial cell death [53,89,90].…”

Section: Mechanisms Of Action Of Phlorotannins Antibacterial Activitymentioning

confidence: 99%

Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions

et al. 2022

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The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It has previously been shown that several bioactive compounds derived from marine algae exhibit antibacterial activity. Similarly, polyphenolic compounds are generally known to possess promising antibacterial capacity, among other capacities. Phlorotannins (PTs), an important group of algae-derived polyphenolic compounds, have been considered potent antibacterial agents both as single drug entities and in combination with commercially available antibacterial drugs. In this context, this article reviews the antibacterial properties of polyphenols in brown algae, with particular reference to PTs. Cell death through various molecular modes of action and the specific inhibition of biofilm formation by PTs were the key discussion of this review. The synergy between drugs was also discussed in light of the potential use of PTs as adjuvants in the pharmacological antibacterial treatment.

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“…This paper is the first report describing an antibiotic activity in the annelids species Abarenicola affinis, Glycera americana and Phragmatopoma moerchi. In close related species like Abarenicola pacifica and Arenicola marina, the synthesis of antimicrobial peptides with a broad antimicrobial spectrum has been reported (Tasiemski et al, 2007;Tasiemski, 2008;Lopez et al, 2014;Mariottini & Grice, 2016;Vitali, 2018). In the genus Glycera, on the contrary, there is not much-related information, because this genus has been studied mainly as a producer of highly toxic neurotoxins that threaten human health rather than of antibiotics (Von Reumont et al, 2014).…”

Section: Annelidamentioning

confidence: 99%

Chilean benthic species identified as a new source of antibiotic substances

Strahsburger

Pizarro

Zúñiga

et al. 2020

Lat. Am. J. Aquat. Res.

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Benthic marine organisms are a natural source of bioactive substances with applications in medicine to treat infections, cancer and other diseases. In Chile, this community possesses rich biodiversity that has been scarcely studied as a producer of bioactive substance so far. For that reason, we studied the potential production of antibiotic substances in 28 benthic species that inhabit the coast of the Tarapacá region in northern Chile, and belong to phylum Porifera, Cnidaria, Mollusca, Sipuncula, Annelida, Echinodermata and Chordata. The antibiotic activity was evaluated on ethanol extract obtained from their entire body or dissected tissues and was tested against Staphylococcus aureus ATCC 25923 with the diffusion agar method. According to the halo diameter, the antibiotic potency was classified as mild, regular or high. In this way, we could identify 21 benthic species as a producer of antibiotic substances with different antibiotic potency. This activity was found in more than one tissue and with regular or high antibiotic activity in the species; Acanthopleura echinata, Chiton cumingsii, Aulacomya atra, Fissurella crassa, Fissurella latimarginata, Luidia magellanica, Stichaster striatus, Arbacia spatuligera, and Loxechinus albus. The extracts obtained from the entire body and showed regular and high antibiotic activity were from the species; Phymanthea pluvia, Abarenicola affinis, Glycera americana, and Ophiactis kroyeri. In conclusion, northern Chile possesses a rich biodiversity of benthic species producer of antibiotic substances, and more research is encouraged to identify these substances with application in medicine.

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The Marine Ecosystem as a Source of Antibiotics

Cited by 10 publications

References 139 publications

Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus

Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus

Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions

Chilean benthic species identified as a new source of antibiotic substances

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