The Marginal Zone/Layer I as a Novel Niche for Neurogenesis and Gliogenesis in Developing Cerebral Cortex

Costa, Marcos Romualdo; Kessaris, Nicoletta; Richardson, William D.; Götz, Magdalena; Hedin-Pereira, Cecília

doi:10.1523/jneurosci.2418-07.2007

Cited by 60 publications

(54 citation statements)

References 83 publications

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“…Nacher and Bonfanti, 2015. To further complicate matters, cortical layer I has also been suggested as a fourth source of potential new neurons as an early postnatal, and perhaps young adult, neurogenic niche for cortical GABAergic interneurons under physiological conditions (Costa et al, 2007;Xiong et al, 2010). The diversity of cell populations suspected to generate or to differentiate into neurons in the piriform cortex allows this primal three-layered cortex to be one of the most suitable and interesting brain regions to study non-canonical neurogenesis in the adult mammalian brain.…”

Section: Limits and Ambiguities Of Cell-proliferation Assays Used To mentioning

confidence: 99%

Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?

et al. 2016

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The expression of early developmental markers such as doublecortin (DCX) and the polysialylated-neural cell adhesion molecule (PSA-NCAM) has been used to identify immature neurons within canonical neurogenic niches. Additionally, DCX/PSA-NCAM + immature neurons reside in cortical layer II of the paleocortex and in the paleo-and entorhinal cortex of mice and rats, respectively. These cells are also found in the neocortex of guinea pigs, rabbits, some afrotherian mammals, cats, dogs, non-human primates, and humans. The population of cortical DCX/PSA-NCAM + immature neurons is generated prenatally as conclusively demonstrated in mice, rats, and guinea pigs. Thus, the majority of these cells do not appear to be the product of adult proliferative events. The immature neurons in cortical layer II are most abundant in the cortices of young individuals, while very few DCX/PSA-NCAM + cortical neurons can be detected in aged mammals. Maturation of DCX/PSA-NCAM + cells into glutamatergic and GABAergic neurons has been proposed as an explanation for the age-dependent reduction in their population over time. In this review, we compile the recent information regarding the age-related decrease in the number of cortical DCX/PSA-NCAM + neurons. We compare the distribution and fates of DCX/PSA-NCAM + neurons among mammalian species and speculate their impact on cognitive function. To respond to the diversity of adult neurogenesis research produced over the last number of decades, we close this review by discussing the use and precision of the term "adult non-canonical neurogenesis."

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Section: Limits and Ambiguities Of Cell-proliferation Assays Used To mentioning

confidence: 99%

Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?

et al. 2016

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“…At present, although mother cells of the layer 1 NPCs have not been identified, the layer 1 NPCs express the markers of the medial ganglionic eminence (MGE), Nkx2.1 and MafB [108,109]. In the developing neocortical layer 1, similar NSCs/NPCs have been found [110]. Thus, such NSCs/ NPCs that are observed during development might be maintained into adulthood.…”

Section: Neurogenesis In the Neocortex Of The Adult Mammal Both Undermentioning

confidence: 99%

Injury-induced neurogenesis in the mammalian forebrain

Ohira

2010

Cell. Mol. Life Sci.

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It has been accepted that new neurons are added to the olfactory bulb and the hippocampal dentate gyrus throughout life in the healthy adult mammalian brain. Recent studies have clarified that brain insult raises the proliferation of neural stem cells/neural progenitor cells existing in the subventricular zone and the subgranular zone, which become sources of new neurons for the olfactory bulb and the dentate gyrus, respectively. Interestingly, convincing data has shown that brain insult invokes neurogenesis in various brain regions, such as the hippocampal cornu ammonis region, striatum, and cortex. These reports suggest that neural stem cells/neural progenitor cells, which can be activated by brain injury, might be broadly located in the adult brain or that new neurons may migrate widely from the neurogenic regions. This review focuses on brain insult-induced neurogenesis in the mammalian forebrain, especially in the neocortex.

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“…However, this generation of new neurons in the postnatal/adult cortex seems to be dependent on unknown signals: those not usually elicited by most types of lesions (Saha et al, 2012;Diaz et al, 2013). It is also still unclear whether these new neurons could be derived from progenitor cells in the parenchyma itself (Palmer et al, 1999;Guo et al, 2010) or the marginal zone/layer 1 (Costa et al, 2007;Ohira et al, 2010).…”

Section: Environmental Signals and Neuronal Plasticity In The Developmentioning

confidence: 99%

Adult neural stem cells: plastic or restricted neuronal fates?

et al. 2013

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SummaryDuring embryonic development, the telencephalon is specified along its axis through morphogenetic gradients, leading to the positional-dependent generation of multiple neuronal types. After embryogenesis, however, the fate of neuronal progenitors becomes more restricted, and they generate only a subset of neurons. Here, we review studies of postnatal and adult neurogenesis, challenging the notion that fixed genetic programs restrict neuronal fate. We hypothesize that the adult brain maintains plastic neural stem cells that are capable of responding to changes in environmental cues and generating diverse neuronal types. Thus, the limited diversity of neurons generated under normal conditions must be actively maintained by the adult milieu.

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The Marginal Zone/Layer I as a Novel Niche for Neurogenesis and Gliogenesis in Developing Cerebral Cortex

Cited by 60 publications

References 83 publications

Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?

Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?

Injury-induced neurogenesis in the mammalian forebrain

Adult neural stem cells: plastic or restricted neuronal fates?

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