The March of the Normoxics: Hyperoxemia and Hemolysis During Cardiopulmonary Bypass*

Editor’s Choice Articles for July

“…Recently, the focus has been on two effects of hyperoxia. First, in pediatric patients undergoing cardiopulmonary bypass (CPB) for cardiac surgery, the observation that a combination of hyperoxia and CPB duration was associated with severe hemolysis (12, 13). Second, in mechanically ventilated children, the finding that potentially excess oxygen exposure was associated with greater odds of mortality (14–16).…”

Editor’s Choice Articles for February

“…The final article reports a prospective evaluation of the association between hyperoxemia and increased cell-free plasma hemoglobin during cardiopulmonary bypass in 100 patients (11). These last two items each come with editorials (12, 13), and it is now clear when we consider this new information along with articles published in PCCM in 2021 that a major theme of investigation is now emerging–the problem of hyperoxia and hyperoxemia. Please take advantage of the Statistical Note in the May 2021 issue of PCCM that covered the topic of confounding and causality in observational studies, particularly with regard to oxygen studies (12).…”