The many roles of solvent in homogeneous catalysis - The reductive amination showcase

One-Pot Synthesis of Fatty Amines: Rh-Catalyzed Hydroaminomethylation of 1-Decene in an Aqueous Microemulsion System—Influence of Reaction Conditions on the Reaction Performance

“…Calculating the activation energies of both reactions of the tandem system increases the uncertainty of the two results. However, these observations are in agreement with the literature, for both hydroformylation (E A = 59 kJ/mol) and reductive amination (E A = 76.2 kJ/mol) by Schomäcker et al and others [22][23][24].…”

Reductive amination of phenol over Pd-based catalysts: elucidating the role of the support and metal nanoparticle size

“…However, this reaction scheme can vary with the catalyst properties (i.e., nature of the metal, metal-support interactions, support acidity, and metal nanoparticle size), phenolic nature, and reaction conditions. For example, the importance of solvents for these reactions was recently studied by Jameel et al 13 The authors proved that the presence of solvents reduces the activation energy of amination, the condensation step occurs in a stepwise manner rather than a concerted manner. Furthermore, solvent molecules that form hydrogen bonds promote the formation of intermediates in terms of thermodynamics and kinetics by actively participating as proton transfer agents.…”

Stable and Continuous Production of Amines via Reductive Amination in a Green Switchable Solvent System with Efficient Water Removal

“…Methanol represents a promising green alternative concerning its classification by SHE criteria and its lower cumulative energy demand in the manufacturing and disposal processes . Furthermore, it has already been shown both computationally , and experimentally that methanol can achieve excellent activities and yields in RA. Thus, methanol was already used for a TMS in hydroaminomethylation, a tandem reaction that includes a reductive amination as the second step .…”