The many facets of polyelectrolytes and oppositely charged macroions complex formation

Ulrich, Serge; Seijo, Marianne; Stoll, Serge

doi:10.1016/j.cocis.2006.08.002

Cited by 111 publications

(105 citation statements)

References 48 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…306 Several mean-field PB theories were implemented to study the complexation of semiflexible PEs with oppositely charged spheres, as a model for NCP formation. 307,308 Some analytical studies predicted a gigantic, up to 10-30 times, sphere overcharging by a thin PE chain wrapped around it, at an optimal [salt] of B0.1 M. 309 More accurate ES PB modelling of complexes of thin PEs with oppositely charged spherical 310 and cylindrical 311 macro-ions however gave rise to a more physical conclusion, namely that undercharged or close to charge-neutral complexes are energetically favored.…”

Section: View Article Onlinementioning

confidence: 99%

Electrostatic interactions in biological DNA-related systems

Cherstvy

2011

Phys. Chem. Chem. Phys.

155

148

View full text Add to dashboard Cite

In this perspective article, we focus on recent developments in the theory of charge effects in biological DNA-related systems. The electrostatic effects on different levels of DNA organization are considered, including the DNA-DNA interactions, DNA complexation with cationic lipid membranes, DNA condensates and DNA-dense cholesteric phases, protein-DNA recognition, DNA wrapping in nucleosomes, and inter-nucleosomal interactions. For these systems, we develop a theoretical framework to describe the physical-chemical mechanisms of structure formation and anticipate some biological consequences. General biophysical principles of DNA compaction in chromatin fibers and DNA spooling inside viral capsids are discussed in the end, with emphasis on electrostatic aspects.

show abstract

Section: View Article Onlinementioning

confidence: 99%

Electrostatic interactions in biological DNA-related systems

Cherstvy

2011

Phys. Chem. Chem. Phys.

155

148

View full text Add to dashboard Cite

show abstract

“…For the present study, organic and hybrid complexes were prepared at Z = 1, i.e. for solutions characterized by the same number densities of positive and negative chargeable ions [35,48].…”

Section: Ii12 -Sample Preparationmentioning

confidence: 99%

Organic versus hybrid coacervate complexes: co-assembly and adsorption properties

Qi¹,

Chapel²,

Castaing³

et al. 2008

Soft Matter

View full text Add to dashboard Cite

We report the co-assembly and adsorption properties of coacervate complexes made from polyelectrolyte-neutral block copolymers and oppositely charged nanocolloids. The nanocolloids put under scrutiny were ionic surfactant micelles and highly charged 7 nm cerium oxide (CeO2) nanoparticles. Static and dynamic light scattering was used to investigate the microstructure and stability of the organic and hybrid complexes. For five different systems of nanocolloids and polymers, we first demonstrated that the electrostatic complexation resulted in the formation of stable core-shell aggregates in the 100 nm range. The microstructure of the CeO2-based complexes was resolved using cryogenic transmission electronic microscopy (Cryo-TEM), and it revealed that the cores were clusters made from densely packed nanoparticles, presumably through complexation of the polyelectrolyte blocks by the surface charges. The cluster stability was monitored by systematic light scattering measurements. In the concentration range of interest, c = 10 -4 -1 wt. %, the surfactant-based complexes were shown to exhibit a critical association concentration (cac) whereas the nanoparticle-polymer hybrids did not. The adsorption properties of the same complexes were investigated above the cac by stagnation point adsorption reflectometry. The adsorbed amount was measured as a function of time for polymers and complexes using anionically charged silica and hydrophobic poly(styrene) substrates. It was found that all complexes adsorbed readily on both types of substrates up to a level of 1 -2 mg m -2 at stationary state. Upon rinsing however, the adsorbed layer was removed for the surfactant-based systems, but not for the cerium oxide clusters. As for the solution properties, these finding were interpreted in terms of a critical association concentrations which are very different for organic and hybrid complexes. Combining the efficient adsorption and strong stability of the CeO2-based core-shell hybrids on various substrates, it is finally suggested that these systems could be used appropriately for coating and anti-biofouling applications. I -IntroductionDevelopment of functional molecular architectures is one of the final goals of modern chemistry, biology and physics. For the design of artificially intelligent devices, fabrication and control of materials at nanometer scale with chemical and physical attributes has been attracting much attention in the last decade. In particular, the complexation of polymers and nanoparticles is opening pathways for engineering novel hybrid structures combining the advantageous properties of both the organic and inorganic moieties [1][2][3]. The first challenge of the present paper was the design of nano-objects with new functionalities and resulting from the association between nanocolloids and polymers. The nanocolloids put under scrutiny were of two kinds: surfactant micelles and inorganic cerium oxide nanoparticles. As for polymers, polyelectrolyte-neutral block copolymers also called double-hydrophilic copolymer...

show abstract

“…Complex formation involving a polyelectrolyte and a macroion ͑e.g., between proteins and DNA or between colloidal particles and synthetic polyelectrolytes͒ is a usual phenomenon in living matter and plays a significant role in several novel nanoscale applications. 1 Recently, the ability of HPs to form complexes with DNA and other biological molecules has been experimentally and computationally explored, [2][3][4] and they were recognized as promising systems for targeted gene transfer. 3,5 Complexes formed by HP molecules and linear synthetic polyelectrolytes demonstrated their capacity to act as solubility enhancer, cytotoxicity reducer, and stabilizer against the enzymatic degradation agents for drug delivery purposes.…”

Section: Introductionmentioning

confidence: 99%

Effects of topology and size on statics and dynamics of complexes of hyperbranched polymers with linear polyelectrolytes

Dalakoglou

Karatasos

Lyulin

et al. 2007

The Journal of Chemical Physics

View full text Add to dashboard Cite

Brownian dynamics simulations with explicit hydrodynamic interactions have been employed to study generic effects of size and topology in noncovalent ͑Coulombic-driven͒ complexes formed by irregular-shaped hyperbranched polymers and linear polyelectrolytes. The behavior of the complexes was explored in detail in terms of static and dynamic properties, both in local and in the entire complex scale. The results were compared to previous studies on perfect dendrimers and other hyperbranched molecules where available. It was found that both molecular weight and structure may impart significant changes to key factors known to be associated with the ability of these systems to take part in relevant nanoscale applications.

show abstract

The many facets of polyelectrolytes and oppositely charged macroions complex formation

Cited by 111 publications

References 48 publications

Electrostatic interactions in biological DNA-related systems

Electrostatic interactions in biological DNA-related systems

Organic versus hybrid coacervate complexes: co-assembly and adsorption properties

Effects of topology and size on statics and dynamics of complexes of hyperbranched polymers with linear polyelectrolytes

Contact Info

Product

Resources

About