The many faces of lung adenocarcinoma: A pictorial essay

Pascoe, Heather; Knipe, Henry; Pascoe, Diane; Heinze, Stefan

doi:10.1111/1754-9485.12779

Cited by 51 publications

(42 citation statements)

References 13 publications

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“…Lesions are usually solitary but can also be multifocal. In a few instances, calcification or cavitation can be seen making it difficult to distinguish from infectious diseases like tuberculosis, pneumonia, or fungal infections [11] (will need more references). The adenocarcinoma's histologic growth pattern is mostly acinar, papillary, and solid; therefore the surfaces in the lobes often have small differentiated leaves and spinous processes [10].…”

Section: Discussionmentioning

confidence: 99%

Miliary Tuberculosis in a Young Patient? Let's Not Forget the Lung Adenocarcinoma!

Zia¹,

Iqbal²,

Narula³

et al. 2020

Cureus

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Lung cancer is one of the most common cancers diagnosed every year and accounts for a major percentage of cancer incidence and mortality annually, especially in men. Lung adenocarcinoma is a subtype of nonsmall cell lung cancer (NSCLC), which is the most common type of lung cancer found in smokers and nonsmokers alike. It is known to have diverse CT chest findings ranging from: ground-glass opacities (GGOs) with partially solid nodules, to single or multiple solid nodules that can be either central or peripheral, to thin-walled cystic lesions. Lesions are usually solitary but may be multifocal. Rarely, these lesions can be calcified or demonstrate cavitation, which can make it difficult to distinguish from an infectious disease like tuberculosis, pneumonia, or even fungal infections. Here, we present a case of a 36year-old Asian male with no significant past medical history, except a 16-pack-year smoking history and recent deployment to Afghanistan, that initially presented with a chief complaint of cough of threeweek duration. His CT scan showed innumerable bilateral pulmonary nodules within both lung fields with a miliary type appearance that ultimately turned out to be adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Miliary Tuberculosis in a Young Patient? Let's Not Forget the Lung Adenocarcinoma!

Zia¹,

Iqbal²,

Narula³

et al. 2020

Cureus

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“…According to He et al, breast and lung cancer account for 37.2% and 24.2% of pituitary metastatic lesions, respectively (10). The main particularity in LAC consists in a large spectrum of appearances and may not appear on the classical chest radiography as it was in our case (11). This should lead to further investigation with cross-sectional imaging at this stage, including basic pathology and CT imaging of the neck, chest, abdomen and pelvis (12).…”

Section: Discussionmentioning

confidence: 60%

Multiple endocrinological failures as a clinical presentation of a metastatic lung adenocarcinoma

Ach

Wojewoda

Toullet

et al. 2020

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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Summary Multiple endocrine metastases are a rare but possible complication of lung adenocarcinoma (LAC). Pituitary metastasis is a rare condition with poor clinical expression. Diabetes insipidus (DI) is its most common presenting symptom. Here we report an original case of a pituitary stalk (PS) metastasis from LAC presenting as central DI followed by adrenal insufficiency (AI) from bilateral adrenal metastasis, without known evidence of the primary malignancy. A 45-year-old woman whose first clinical manifestations were polyuria and polydipsia was admitted. She was completely asymptomatic with no cough, no weight loss or anorexia. Chest radiography was normal. Brain MRI showed a thick pituitary stalk (PS). DI was confirmed by water restriction test and treated with vasopressin with great clinical results. Explorations for systemic and infectious disease were negative. Few months later, an acute AI led to discovering bilateral adrenal mass on abdominal CT. A suspicious 2.3 cm apical lung nodule was found later. Histopathological adrenal biopsy revealed an LAC. The patient received systemic chemotherapy with hormonal replacement for endocrinological failures by both vasopressin and hydrocortisone. We present this rare case of metastatic PS thickness arising from LAC associated with bilateral adrenal metastasis. Screening of patients with DI and stalk thickness for lung and breast cancer must be considered. Multiple endocrine failures as a diagnostic motive of LAC is a rare but possible circumstance. Learning points: Adrenal metastasis is a common location in lung adenocarcinoma; however, metastatic involvement of the pituitary stalk remains a rare occurrence, especially as a leading presentation to diagnose lung cancer. The posterior pituitary and the infundibulum are the preferential sites for metastases, as they receive direct arterial blood supply from hypophyseal arteries. Patients diagnosed with diabetes insipidus due to pituitary stalk thickness should be considered as a metastasis, after exclusion of the classical systemic and infectious diseases. The diagnosis of an endocrinological metastatic primary lung adenocarcinoma for patients without respiratory symptoms is often delayed due to a lack of correlation between endocrinological symptoms and lung cancer. The main originality of our case is the concomitant diagnosis of both endocrinological failures, as it was initiated with a diabetes insipidus and followed by an acute adrenal insufficiency.

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“…The green lines indicated that acetylation of the enzymes, which mediated the specific chemical reaction, was significantly reduced cases. In contrast to other types of lung cancer, lung adenocarcinoma typically develops more slowly [29,30]. Numerous studies have shown that genetic and epigenetic alterations play a critical role in oncogenesis and the progression of tumors.…”

Section: Discussionmentioning

confidence: 99%

Global analysis of lysine acetylome reveals the potential role of CCL18 in non‐small cell lung cancer

et al. 2021

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C-C motif chemokine 18 (CCL18) belongs to the chemokine CC family and is predominantly secreted by M2-tumor-associated macrophages. It has been reported to be associated with various diseases and malignancies. Previous studies showed that CCL18 promotes metastasis by activating downstream kinases. However, it remains unknown whether CCL18 regulates post-translational modifications, other than phosphorylation, during tumorigenesis. Here, we demonstrate that CCL18 is up-regulated in non-small cell lung cancer (NSCLC) and is involved in regulating the lysine acetylome in A549 cells. Using the combination of SILAC labeling and high-efficiency acetylation enrichment methods, we identified 1372 lysine acetylation (Kac) sites on 796 proteins in CCL18-treated A549 cells. Among the identified Kac sites, 147 from 126 proteins were down-regulated and seven from five proteins were up-regulated with fold changes more than two and the p-value less than 0.05. Bioinformatics analysis further showed that the proteins with down-regulated acetylation play critical roles in glycolysis, oxidative phosphorylation, tricarboxylic acid cycle, and pentose phosphate pathway in A549 cells. These results suggest that CCL18 may be involved in the development of NSCLC by regulating acetylation of the proteins in many fundamental cellular processes, especially the metabolic reprogramming of tumor cells.

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The many faces of lung adenocarcinoma: A pictorial essay

Cited by 51 publications

References 13 publications

Miliary Tuberculosis in a Young Patient? Let's Not Forget the Lung Adenocarcinoma!

Miliary Tuberculosis in a Young Patient? Let's Not Forget the Lung Adenocarcinoma!

Multiple endocrinological failures as a clinical presentation of a metastatic lung adenocarcinoma

Global analysis of lysine acetylome reveals the potential role of CCL18 in non‐small cell lung cancer

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