The Many Faces of Arrhythmogenic Cardiomyopathy: An Overview

Abstract

Arrhythmogenic cardiomyopathy (AC) is a disease that involves electromechanical uncoupling of cardiomyocytes. This leads to characteristic histologic changes that ultimately lead to the arrhythmogenic clinical features of the disease. Initially thought to affect the right ventricle predominantly, more recent data show that it can affect both the ventricles or the left ventricle alone. Throughout the recent era, diagnostic modalities and criteria for AC have continued to evolve and our understanding of its clinical features in different age groups as well as the genotype to the phenotype correlations have improved. In this review, we set out to detail the epidemiology, etiologies, presentations, evaluation, and management of AC across the age continuum.

Arrhythmogenic Cardiomyopathy of the Right Ventricle: Clinical and Physiopathological Aspects

“…This may include, according to Tadros et al (2023): antithrombotic therapy in the case of ventricular aneurysms or depressed ventricular function or anticoagulation in the case of atrial fibrillation or known thrombosis or thromboembolism, antiarrhythmic therapies that may include beta-blockers, electrical cardioversion, in some cases endoand epicardial catheter ablation of the focus of arrhythmia may be considered, although the risk of recurrence of arrhythmias is relatively high given ongoing myocardial pathology.…”