“…Earlier studies were referral center based, 12,17,18,20,[30][31][32][33][34][35][36] which can lead to overrepresentation of patients with more severe disease or lacked comparison with control subjects from the general population. 11,12,14,15,[17][18][19][20]22,[32][33][34][35][36][37] Because of our large sample size, we were able to conduct subgroup analyses while maintaining statistical robustness. Also, because more than 90% of patients with IBD in Canterbury were included in the study, the results are more likely to be more generalizable.…”