“…Once stability has been achieved, the main question is whether an extremity saving procedure or amputation should be performed. To appropriately address this issue several factors need to be considered, and the decision should be taken on an individual basis, as to this date, none of the currently available “severity” scales, such as, MESI, PSI, HFS, MESS, LSI or NISSA have been validated for decision making in prospective trials for open population nor have shown any benefit in the treatment of this patients [4,5].…”