The management of tumor motions in the stereotactic irradiation to lung cancer under the use of Abches to control active breathing

Tarohda, Tohru; Ishiguro, Mitsuru; Hasegawa, K.; Kohda, Yukihiko; Onishi, Hiroaki; Aoki, Takeshi; Takanaka, Tsuyoshi

doi:10.1118/1.3604151

Cited by 27 publications

(19 citation statements)

References 22 publications

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“…A BlueBAG system (Medical Intelligence, Munich, Germany) was used to immobilize patients. To maintain tumor positions during irradiation, patients were instructed in the self-controlled breath-hold technique using an Abches (APEX Medical, Tokyo, Japan) respiratory monitoring system [20]. This system was used during CT scanning for treatment planning and irradiation, and breath was held at inspiration or expiration.…”

Section: Methodsmentioning

confidence: 99%

Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

Hayashi

Tanaka

Kajiura³

et al. 2014

Radiat Oncol

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BackgroundStereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) is primarily a treatment option for medically inoperable patients, who are often elderly. However, few studies report the effects of SBRT in elderly patients. Thus, we retrospectively analyzed clinical outcomes and feasibility following treatment of very elderly patients (age ≥ 85 years) with stage Ι NSCLC and younger patients (age < 85 years) with SBRT in our institution.MethodsFrom January 2006 to December 2012, 81 patients (20 very elderly; median age, 80 years; age range 64–93 years) with stage Ι NSCLC received SBRT. Prescription doses of 48 Gy were delivered in 4 fractions over 2 weeks or doses of 60 Gy were delivered in 10 fractions over 3 weeks.ResultsLocal control was achieved in 91.8% of all patients at 3 years (83.1% and 93.8% of very elderly and younger patients, respectively), and the 3-year overall survival (OS) rate was 69.4% (40.7% and 75.0% of very elderly and younger patients, respectively). OS rates were significantly shorter for the very elderly group than for the younger group, with a 3-year cause-specific survival (CSS) rate of 77.9% (50.4% and 81.6% of very elderly and younger patients, respectively) and a 3-year progression-free survival (PFS) rate of 59.5% (44.7% and 63.5% in very elderly and younger groups, respectively). Multivariate analysis revealed a significant correlation between T stage and OS. Grades 2 and 3 radiation pneumonitis (RP) occurred in 7 (8.6%) and 2 (2.5%) patients, respectively. Among patients of very elderly and younger groups, grade 2 RP occurred in 4 (20%) and 3 (4.9%) patients, and grade 3 occurred in 2 (10%) and 0 (0%) patients, respectively. No grade 4 or 5 toxicity was observed, RP was significantly more severe among very elderly patients.ConclusionsSBRT for stage Ι NSCLC was well tolerated and feasible in very elderly patients. The efficacy of SBRT was comparable to that achieved in younger patients, although very elderly patients experienced significantly more severe RP. Although this study cohort included only 20 very elderly patients, the present data suggest that decreasing volumes of normal lung tissues exposed to ≥ 20 Gy and mean lung doses reduces the risk of RP in very elderly patients. The present data warrant studies of larger very elderly cohorts.

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Section: Methodsmentioning

confidence: 99%

Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

Hayashi

Tanaka

Kajiura³

et al. 2014

Radiat Oncol

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“…This device has been extensively used, particularly in Asia, to treat multiple sites, including lung, liver, and breast cancer. In a study including 32 NSCLC, Tarohda, et al concluded that the Abches device could be effectively used to obtain appropriate reproducibility of tumor position during lung SABR under breath holding conditions [5]. Lee, et al observed that Abches could be used to treat left-sided breast cancer in a deep inspiration breath-hold setting with potential dose reduction to the heart [7].…”

Section: Figure 3: Ct Images and Treatment Isodoses Of A Marginal Bhmentioning

confidence: 99%

“…The benefits of Abches monitoring device to ensure reproducible BH radiotherapy treatment have been established in several previous studies [1,[4][5][6][7]. This device has been extensively used, particularly in Asia, to treat multiple sites, including lung, liver, and breast cancer.…”

Section: Figure 3: Ct Images and Treatment Isodoses Of A Marginal Bhmentioning

confidence: 99%

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Accuracy of Breath-hold CT in Treatment Planning for Lung Stereotactic Ablative Radiotherapy

Mathieu¹,

Martel²,

Campeau³

et al. 2014

Cureus

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“…6, 7) 적 향상을 저하 시키는 원인이 되기도 하였다, [13] 방사선이 정상 간에 노출이 되었을 경우 방사선으 로 혈관이 막히면서 간이 손상된다는 연구결과가 보 고 되었으며 [14] , 방사선으로 인한 간질환은 방사선 치 료 후 보통 4-8주 후에 발생하지만 문헌에 따르면 방 사선 치료 후 이르면 2주 후부터 늦으면 7개월 후까지 도 발생하는 것으로 보고되고 있다. …”

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Comparison with ABCHES and Abdomen Compression Device in Respirational Radiation Therapy on Patients in Hepatocellular Carcinoma

Cho¹,

Byun²,

Kim³

2012

Journal of the Korean Society of Radiology

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Abstract4D-Radiation Therapy is the optimal treatment to track moving organs(tumor) and give the appropriate prescription dose to tumor and low radiation dose to normal tissue surrounding tumor volume. The ABCHES is a 4DRT devices maintaining shallow breathing to patients. It allows the tumor's movement was minimize. Meanwhile, Abdominal compression device is limited the breath compressing abdomen on patients. In this paper we will quantitative analysis the movement of tumor on only ABCHES versus ABCHES with Abdomal compression device and Analysis tumor dose and normal tissue's dose by Dose Volume Histogram on two parts. The result of Comparision ABCHES and ABCHES with Abdominal compression device, SI(Superior-Inferior) direction, AP(Anterior-Posterior) direction and LR(Left-Right) direction was limited 1.0 mm, 0.2 mm, 0.2 mm(average). and also reduction rate of voluume in HPTV was 16 ± 2%, and LPTV was 15.8 ± 0.8% under only using ABCHES and ABCHES with compression. The analysis dose volume histogram was more radiation dose in ABCHES and abdominal compression device than only using ABCHES, and less normal tissue-ipsilateral lung, whole lung, kidney-dose in ABCHES and abdominal compression device than only using ABCHES. The overall analysis was ABCHES with abdominal compression better than only using ABCHES method. In hereafter it will be studies that limitation of ABCHES and abdomonal compression device. In other words, patient's discomfort on compression intensity, method of application on patient with inaccurate respiration cycle.

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The management of tumor motions in the stereotactic irradiation to lung cancer under the use of Abches to control active breathing

Abstract: Respiratory control with high accuracy and reproducibility is required for high-precision radiotherapy of inoperable nonsmall-cell lung cancer and was achieved using Abches in this study.

Cited by 27 publications

References 22 publications

Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

Accuracy of Breath-hold CT in Treatment Planning for Lung Stereotactic Ablative Radiotherapy

Comparison with ABCHES and Abdomen Compression Device in Respirational Radiation Therapy on Patients in Hepatocellular Carcinoma

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