The management of periorbital nodular fasciitis using intra-lesional triamcinolone: a case report and review of the literature

Keren, Shay; Hildebrand, Darius; Wilson, Shaun; McCallum, Ewan; Norris, Jonathan H.

doi:10.1080/01676830.2020.1787465

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The actual most emphasized treatment in children with this type of rapid growing masses is sonographic control in superficial lesions with biopsy at early clinical presentation and surgical resection with keeping functional structures intact. If other treatment options like local corticosteroid injections [24] or systemic corticosteroids are helpful in children is somewhat speculative because of its mostly solitary aspect, the fast growth and the need to biopsy compared to the sometimes multiple lesions in adults [25]. To our best knowledge, this is the first case of a proven congenital nodular fasciitis of the skin and the first case of such a congenital pediatric lesion of the trunk.…”

Section: Discussionmentioning

confidence: 94%

Congenital nodular fasciitis: an extremely rare entity with review of literature

Wagner

Ulrich

2022

Ann Pediatr Surg

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Background Nodular fasciits is thought to be a benign superficial nodular disease, which most often occurs in the medium age of adolescence, mainly in the subcutaneous or fascial plane on the upper extremities and trunk. The percentage of this entity in children compared to adults is less than 10%. Most cases in childhood were reported at the head and neck region, therefore often renamed to cranial or extracranial fasciitis. These lesions often consists of sarcoma like structures. Preoperative imaging is often unspecific and the standard of treatment in children is biopsy or in some cases complete resection with narrow margin depending on size or location of the lesion. Case presentation We present a clinical case of a female newborn with a congenital nodular presternal mass. Biopsy revealed nodular fasciits by testing on USP6 gen rearrangement. With ongoing growth of her nodular thoracic tumor, she underwent complete resection with primary closure. We followed her clinical course over more than 3 years and give a review of the literature. Conclusion Only a minority of reports are documented with a neonate onset and none with a real congenital. We hereby presented the first case in literature of a proven congenital fasciits other than cranial/extracranial in a newborn and her clinical course.

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Section: Discussionmentioning

confidence: 94%

Congenital nodular fasciitis: an extremely rare entity with review of literature

Wagner

Ulrich

2022

Ann Pediatr Surg

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“…Recurrence of NF after excision is rare but occasional instances have been observed, with greater concern for persistent lesions on the face in both children and adults 7,8 . A few reports exist of successful treatment of NF with intralesional steroid injections and fractional ablative laser 8,9 …”

Section: Introductionmentioning

confidence: 99%

“…7,8 A few reports exist of successful treatment of NF with intralesional steroid injections and fractional ablative laser. 8,9 NF can represent a challenging histopathologic entity because of its spindled and often poorly circumscribed profile, high mitotic activity, and variable staining pattern. 10,11 The original moniker "pseudosarcomatous fibromatosis" alludes to these concerning features apparent on initial review.…”

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confidence: 99%

USP6 rearrangement in pediatric nodular fasciitis

et al. 2022

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Nodular fasciitis (NF) is a myofibroblastic proliferation that is uncommonly present in pediatric patients. These benign neoplasms can masquerade as more insidious sarcomatous proliferations on both clinical exam and initial histopathologic review, often prompting undue concern in patients, parents, and providers. While immunohistochemical analysis of NF can be variable, adding to the diagnostic uncertainty, molecular analysis documenting ubiquitin‐specific protease 6 (USP6) gene rearrangement can help confirm the diagnosis as an association between NF and USP6 overexpression was first identified 10 years ago in an analysis that found rearrangements of the involved locus in over 90% of studied samples. In this report, we review one case of NF located on the chin of a nine‐year‐old girl in which molecular testing was essential to secure the correct diagnosis, and provide a summary of documented cases of USP6 overexpression in transient pediatric neoplasms.

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Orbital nodular fasciitis in the pediatric population: a case report and review of the literature

Navarrete

Maya

Benshushan

et al. 2021

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The management of periorbital nodular fasciitis using intra-lesional triamcinolone: a case report and review of the literature

Cited by 4 publications

References 23 publications

Congenital nodular fasciitis: an extremely rare entity with review of literature

Congenital nodular fasciitis: an extremely rare entity with review of literature

USP6 rearrangement in pediatric nodular fasciitis

Orbital nodular fasciitis in the pediatric population: a case report and review of the literature

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