The Management of Patients with Metastatic Prostate Cancer during the COVID-19 Pandemic

Abstract

<jats:p> During the ongoing global pandemic of coronavirus disease 2019 (COVID-19), the benefit of treating patients with cancer must be weighed against the COVID-19 infection risks to patients, staff and society. Prostate cancer is one of the most common cancers among men and raises particular interest during the pandemic as recent reports show that the TMPRSS2 (and other serine proteases), which facilitate the entry, replication and budding of the virion from a cell, can be inhibited using androgen deprivation therapy. Nevertheless, patients with metastatic prostate cancer commonly receive chemotherapy which may compromise their immune system. This paper aims to address the current status of the COVID-19 in patients with cancer overall and suggests an optimal approach to patients with metastatic prostate cancer. </jats:p>

Is there any association of COVID‐19 with testicular pain and epididymo‐orchitis?

“…If we evaluated in terms of genitourinary pathologies, acute kidney failure is among the most frequently studied subjects 5,6 . Studies published of the relationship between the genitourinary cancers and COVID‐19 has usually focused on the management of prostate cancer (PCa) or bladder cancer (BC) 7‐14 . In these studies, the roles of CoV presence in the diagnosis and treatment of urinary system pathologies were mentioned and disease management was explained with general recommendations.…”

“…5,6 Studies published of the relationship between the genitourinary cancers and COVID-19 has usually focused on the management of prostate cancer (PCa) or bladder cancer (BC). [7][8][9][10][11][12][13][14] In these studies, the roles of CoV presence in the diagnosis and treatment of urinary system pathologies were mentioned and disease management was explained with general recommendations.The relationship between testicular pain and COVID-19 is one of the least informed subjects among the existing urological diseases. In the current literature, only one case report was published regarding…”

­­The Combined Outcomes of the COVID-19 Pandemic and a Collapsing Economy on&nbsp;Mental Well-Being: A Cross-Sectional Study

“…Such strategies would include measures to protect them against the COVID-19, educate them on the importance of communicating with their healthcare providers and adhering to treatments, in addition to developing strategies for telemedicine and remote consultation if the lockdown persists 60 . Speci c recommendations have already been developed in Lebanon for the geriatric population 46 and cancer patients [61][62][63] , even if their implementation could face obstacles due to the reluctance of patients to change 64 .…”

Supportive care in patients with cancer during the COVID-19 pandemic

“…This has been the subject of many published expert opinions since the start of the COVID-19 outbreak. 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 These are not evidence-based, in the sense that they have not been developed following prospective studies. Nonetheless, they can help inform clinicians on the most appropriate strategies to reduce the risk of exposure to SARS-CoV-2.…”