The management of patients with the short bowel syndrome

Platell, Cameron; Coster, Jane; Mccauley, Rosalie; Hall, John C.

doi:10.3748/wjg.v8.i1.13

Cited by 39 publications

(25 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TPN is the most important factor responsible for prolonging the lives of patients with SBS. In the initial stages after massive resection of bowel, TPN should begin early to attain positive nitrogen balance and to prevent severe weight loss [12,13] . TPN has been shown to greatly increase the chances of long-term survival.…”

Section: Discussionmentioning

confidence: 99%

Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients

Wu¹,

Wu²,

Wu³

2003

WJG

View full text Add to dashboard Cite

AIM:To evaluate the effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients. METHODS:Thirty-eight patients with severe short-bowel syndrome (SBS) were employed in the present study, whose average length of jejunum-ileum was 35.8±21.2 cm. The TPN treatment was initiated early to attain positive nitrogen balance and prevent severe weight loss. The TPN composition was designated to be individualized and altered when necessary. Enteral feeding was given as soon as possible after resection and increased gradually. Meals were distributed throughout the day. Eight patients received treatment of growth hormone (0.14 mg/kg.day) and glutamine (0.3 g/kg.day) for 3 weeks. D-xylose test, 15

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients

Wu¹,

Wu²,

Wu³

2003

WJG

View full text Add to dashboard Cite

show abstract

“…Further studies are needed to elucidate the precise mechanism by which neurotrophins influence smooth muscle contractility and/or enteric nerve functions in the human gastrointestinal tract. Gut motility disorder is common in clinical practice [29][30][31][32][33] , and its suitable treatment should be studied [34][35][36][37][38] . In this respect, our data indicate that neurotrophins are the promising agents capable of modifying transit in the entire gastrointestinal tract and may provide novel treatments for patients with disturbed gut motility, such as Hirschspnmg's disease [28,39] .…”

Section: Discussionmentioning

confidence: 99%

Effects of neurotrophins on gastrointestinal myoelectric activities of rats

Ning-LiChai¹,

LeiDong²,

Zong-FangLi³

et al. 2003

WJG

View full text Add to dashboard Cite

AIM:To observe the effects of mouse nerve growth factor (NGF), rat recombinant brain derived neurotrophic factor (rm-BDNF) and recombinant human neurotrophin-3 (rh-NT-3) on the gastrointestinal motility and the migrating myoelectric complex (MMC) in rat. METHODS:A randomized, double-blinded, placebo-controlled experiment was performed. 5-7 days after we chronically implanted four or five bipolar silver electrodes on the stomach, duodenum, jejunum and colon, 21 experimental rats were coded and divided into 3 groups and injected NGF, rm-BDNF, rh-NT-3 or placebo respectively via tail vein at a dose of 20 µg·kg -1 . The gastrointestinal myoelectrical activity was recorded 2 hours before and after the test substance infusions in these consciously fasting rats. RESULTS:The neurotrophins-induced pattern of activity was characterized by enhanced spiking activity of different amplitudes at all recording sites, especially in the colon. In the gastric antrum and intestine, only rh-NT-3 had increased effects on the demographic characteristics of electrical activities (P<0.05), but did not affect the intervals of MMCs. In the colon, all the three kinds of neurotrophins could significantly increase the frequency, amplitude and duration levels of spike bursts, and also rh-NT-3 could prolong the intervals of MMC in the transverse colon (25±11 min vs 19±6 min, P<0.05). In the distal colon rh-NT-3 could evoke phase III-like activity and disrupt the MMC pattern, which was replaced by a continuously long spike bursts (LSB) and irregular spike activity (ISA) for 48±6 min. CONCLUSION:Exogenous neurotrophic factors can stimulate gut myoelectric activities in rats.

show abstract

“…So beginning with oral or enteral nutrition must start as soon as possible. Nutrients also provide substrates to reproduce enterocytes and can stimulate the release of trophic factors [29][30][31]. Intestinal adaptation can be stimulated by secretions and gastrointestinal hormones.…”

Section: Intestinal Adaptationmentioning

confidence: 99%

Surgical Options in Short Bowel Syndrome

Rodríguez-Montes¹

2016

J.Paedi.Care.Inol

View full text Add to dashboard Cite

Short bowel syndrome is characterized by a significant reduction in the effective intestinal surface by an anatomical or functional loss of the small intestine. It mainly occurs after extensive bowel resection, intestinal intrinsic disease or surgical bypass. The main complications are mal-digestion, malnutrition, dehydration and, potentially, lethal lesions. The management, based on appropriate and individualized nutritional support, is complexand requires a multidisciplinary approach including dietary, fluid and pharmacological management, co-morbid disease management and, sometimes, surgery. Numerous surgical procedures to relieve the consequences of massive intestinal resection have been devised, but many have not been employed in human clinics and have remained in the experimental surgery field. The choice of technique is dictated by the patient´s underlying pathophysiology and includes such factors as age, intestinal transit time, length of remnant bowel, presence of intact colon, degree of small bowel dilation, and others. Autologous intestinal reconstruction includes various techniques which manipulate the bowel surgically to facilitate the bowel adaptation process and restoration of enteral nutrition. The most accepted techniques are those elongating the bowel that may be applied only on dilated bowel. However, the intestinal transplantation can be a curative alternative for patients in whom intestinal rehabilitation attempts have failed and who are at risk of life-threatening parenteral nutrition complications.

show abstract

The management of patients with the short bowel syndrome

Cited by 39 publications

References 83 publications

Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients

Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients

Effects of neurotrophins on gastrointestinal myoelectric activities of rats

Surgical Options in Short Bowel Syndrome

Contact Info

Product

Resources

About