The management of pancreatic metastasis from synovial sarcoma of the soft tissue: A case report

Bouhani, Malek; Sakhri, Saida; Jaïdane, Olfa; Kammoun, S.; Maher, Slimene; Chargui, Riadh; Rahal, Khaled

doi:10.1177/2036361320983691

Cited by 4 publications

(2 citation statements)

References 33 publications

(56 reference statements)

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“…It is less frequent than carcinoma and affects mostly adolescents. Synovial sarcomas are malignant soft tissue tumors of unknown etiology ( 4 , 5 ). These tumors can appear in a variety of sites and are currently considered to result from a mutation in mesenchymal cells.…”

Section: Discussionmentioning

confidence: 99%

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Ali¹,

Seerwan

Ali³

et al. 2023

Med Int

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Synovial sarcoma is a mesenchymal spindle cell tumor. Primary pancreatic sarcomas are extremely rare. the present study describes a rare case of synovial sarcoma in the head of the pancreas. a 35-year-old male presented with left upper quadrant abdominal pain. an endoscopic ultrasound examination revealed a complex solid-cystic lesion in the pancreatic head. He had undergone pancreaticoduodenectomy (Whipple procedure). a histological examination yielded negative results for aE1/aE3, CD10, S100, CD34, desmin, smooth muscle actin, β-catenin, CD117, HMB45, chromogranin and synaptophysin. However, the results were positive for tlEI and vimentin, which is consistent with synovial sarcoma. Synovial sarcoma is a soft tissue malignant tumor. Primary pancreatic sarcomas frequently present as large, high-grade tumors in the pancreatic head. Histologically, there are several types of synovial sarcoma, such as monophasic, biphasic and poorly differentiated. a histological examination is necessary for the diagnosis as the imaging findings are not specifically suggestive of synovial sarcoma. the preferred course of treatment is complete resection with wide margins, followed by adjuvant chemotherapy and/or radiotherapy. Primary mesenchymal tumors of the pancreas are extremely uncommon. as a result, a diagnosis requires careful evaluation. Surgical resection is the main modality of treatment.

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Section: Discussionmentioning

confidence: 99%

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Ali¹,

Seerwan

Ali³

et al. 2023

Med Int

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show abstract

“…Renal cell carcinoma, colorectal cancer, melanoma, and lung cancer are the most frequent primary malignancies that cause pancreatic metastases; pancreatic metastases from synovial soft tissue sarcoma are extremely uncommon[ 23 - 26 ]. A review of pancreatic metastases of sarcomas other than clear cell sarcoma showed that the primary tumor was located in the lower limbs[ 27 ]. This observation led scientists to hypothesize that a shunt between the lower limbs and the pancreas existed.…”

Section: Metastatic Clear Cell Sarcoma In the Pancreasmentioning

confidence: 99%

Metastatic clear cell sarcoma of the pancreas: A sporadic cancer

Gebbia,

Carnaghi

2024

World J Clin Cases

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Primary or secondary clear cell sarcoma of the pancreas is an exceedingly rare and aggressive disease. In addition to pathology, molecular analysis is pivotal in differential diagnosis, especially with malignant melanoma. A key aspect in identifying clear cell sarcoma is specific genetic alterations, notably the translocation of t(12;22) (q13;q13), a diagnostic hallmark of this sarcoma subtype, which is absent in malignant melanoma. Treatment of primary clear cell sarcoma of the pancreas is the same as that for adenocarcinoma.

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Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy

et al. 2023

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Background Synovial sarcoma is a malignant tumor that constitutes up to 10% of all soft-tissue sarcomas. The most frequent metastatic sites of synovial sarcoma are the lungs, lymph nodes, and bone, whereas pancreatic metastasis is extremely rare. Here, we report a case of pancreatic metastasis of synovial sarcoma. Case presentation Nine years before presentation, a 31-year-old woman underwent extensive resection of the primary tumor after chemotherapy for left upper extremity synovial sarcoma. Six months before presentation, interscapulothoracic amputation was performed for an enlarged mass in the left upper extremity; the patient was treated with pazopanib. Three months before presentation, chest computed tomography showed multiple lung metastases; during subsequent follow-up, abdominal computed tomography revealed a pancreatic metastasis of synovial sarcoma. The doubling time of the pancreatic tumor was 14 days, and it grew rapidly. Furthermore, treatment-resistant pancreatitis symptoms were detected; thus, we performed distal pancreatectomy and administered one course of a 70% dose of trabectedin. However, the patient died of rapid progression of lung metastasis and respiratory failure within 2 months after surgery. Conclusions Pancreatectomy may be carefully performed in cases of isolated pancreatic metastasis. However, the presence of other distant extrapancreatic metastases (e.g., uncontrolled lung metastases) may rule out pancreatectomy treatment.

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The management of pancreatic metastasis from synovial sarcoma of the soft tissue: A case report

Cited by 4 publications

References 33 publications

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Metastatic clear cell sarcoma of the pancreas: A sporadic cancer

Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy

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