The Management of Infants for Cardiac Surgery under Deep Hypothermia

Brown, T. C. K.; Clarke, C. P.; Shanahan, E. Anne; Mckie, B. D.; Wood, H. M.; Thorp, Eustace

doi:10.1177/0310057x7200100206

Cited by 11 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several palliative operations were developed because corrective surgery in babies under 10 kg only became feasible about 1969 when deep hypothermia (18⁰c) and circulatory arrest became a viable option. [7] Safety was enhanced by the addition of carbon dioxide to the oxygenator gas during cooling so that the corrected CO2 remained normal and the hemoglobin -oxygen dissociation curve moved to the right. This increased oxygen release to the tissues prior to circulatory arrest.…”

mentioning

confidence: 99%

Early Developments in Anesthesia and Pain Management with Special Reference to Children

Brown¹

2016

JARPM

View full text Add to dashboard Cite

It is useful when inaugurating a new journal on Anesthesia Research and Pain management to know something about the beginnings and development of the field. Earlier doctors giving anesthetics had many problems to overcome. They had to try new drugs and develop new techniques and how best to perform them. Some of these have passed into oblivion but others are now taken for granted without the thought that someone had to work them out. It is hoped that this paper will provide some interesting insights about what has gone before. Ether and chloroform dominated the first 100 years of anesthesia, along with nitrous oxide, the analgesic properties of which Humphrey Davy suggested as early as 1799 "might be useful to relieve pain in operations where there was no great effusion of blood". The analgesic properties of these drugs were recognized during their use as party drugs when they were inhaled. From the beginning, there were a few individuals like John Snow and Joseph Clover who recorded their experience and developed appropriate equipment for their administration. John Snow's ether inhaler was remarkable because he had baffles which extended the time the ether was exposed to the air flowing over it to enhance vaporization and it had a water bath to reduce heat loss which is associated with ether vaporization. At first, the liquid drugs were administered drop by drop on to a handkerchief or cloth held over the patient's face. Then metal framed masks, such as Schimmelbusch's, were constructed to hold gauze on

show abstract

mentioning

confidence: 99%

Early Developments in Anesthesia and Pain Management with Special Reference to Children

Brown¹

2016

JARPM

View full text Add to dashboard Cite

show abstract

“…Following resuscitation, the hypothermic one recovered normally but the other one developed cerebral palsy and died young (3). By the early 1970s, we were familiar with induced hypothermia for infant cardiac surgery (3) and neurosurgery which provided brain protection, and also with induced hypotension with sodium nitroprusside which reduced bleeding. Both these adjuncts provided added safety and were used for many years in conjunction with liver tumor surgery (2).…”

mentioning

confidence: 99%