The management of dry skin with topical emollients – recent perspectives

Proksch, Ehrhardt; Lachapelle, Jean‐Marie

doi:10.1111/j.1610-0387.2005.05068.x

Cited by 92 publications

(39 citation statements)

References 33 publications

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“…However, the biophysical measurements indicated a difference between effects exerted by the use of PIPJ emollient and those exerted by the petrolatum-based lotion or cream. Thus, biophysical parameters represent an important adjunct in the comprehensive evaluation of emollient effects on skin barrier function [4]. Comparing our results with earlier results of studies investigating patients with definite AD, no significant correlations between SCORAD and TEWL or SCH were observed in our patients with dry skin and predisposition to AD [63].…”

Section: Discussionsupporting

confidence: 70%

“…Regular treatment with emollients may be a vital factor in the management of this skin condition in children with dry skin and atopic predisposition [4,5]. The clinical evaluations revealed a similar course of the skin condition in both groups.…”

Section: Discussionmentioning

confidence: 91%

“…An impaired skin barrier function is typically found in dry skin, which exhibits increased values of transepidermal water loss (TEWL) and skin surface pH (pH) [2,3,4,5]. In addition, this epidermal barrier insufficiency is reflected by a decrease in stratum corneum hydration (SCH) and decreased amounts of natural moisturizing factor (NMF) [6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition. Objectives: We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients. Methods: Children aged 2-6 years with dry skin and atopic predisposition were randomized into 2 groups: group 1 received emollients containing PIPJ and natural lipids, while group 2 received petrolatum-based emollients. Skin condition and biophysical properties of the skin barrier were assessed at inclusion and weeks 4, 12 and 16. Results: Skin condition improved significantly in all children. Comparing the groups, children treated with emollients containing PIPJ showed significantly higher stratum corneum hydration values and significantly lower transepidermal water loss values at week 16 on the forearm and forehead. A significant decrease in skin pH was noted in group 2 on the forearm and forehead; group 1 showed a stable course. Conclusion: Early intervention with emollients in children with dry skin condition and atopic predisposition may improve their skin condition during daily emollient application. PIPJ-based formulations may be helpful to maintain skin barrier integrity.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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“…Furthermore, biophysical parameters represent an important adjunct in the comprehensive evaluation of emollient effects on skin barrier function [7,38]. The skin microtopography confirmed the decrease in skin dryness measured by the SCORAD showing a significantly diminished scaling on the leg in all groups (G1-G3; fig.…”

Section: Discussionmentioning

confidence: 55%

Children with Dry Skin and Atopic Predisposition: Outcome Measurement with Validated Scores for Atopic Dermatitis

Sawatzky¹,

Schario²,

Stroux³

et al. 2016

Skin Pharmacol Physiol

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Background: Dry skin is a common skin condition in childhood. Few studies exist investigating the influence of daily skin care on dry skin in infants at risk of developing atopic dermatitis (AD). We aimed to assess the effect of skin care on dry skin in this special cohort using validated scores for AD and analysis of skin microtopography. Methods: 43 children were randomized to group 1 (G1) and group 2 (G2) and 22 infants to group 3 (G3). During 16 weeks, G1 and G3 applied daily a plant-based emollient and G2 a petrolatum-based emollient. The core outcome was assessed by Severity Scoring of Atopic Dermatitis (SCORAD) and Patient-Oriented SCORing Atopic Dermatitis (PO-SCORAD). The influence on the parents' life was evaluated by a questionnaire and microtopography by Visioscan® VC 98. Results: The SCORAD index declined significantly until week (W) 16 in all groups (p ≤ 0.041). The sleeplessness score analyzed by PO-SCORAD was highly reduced after W12 in G1 and after W16 in G2 (p ≤ 0.030). The influence on the parents' anxiety was reduced in G3 at W12 and W16 (p = 0.016). The Visioscan parameter scaliness strongly diminished at W4 (p ≤ 0.049) and W16 (p ≤ 0.013) in all groups. Conclusions: This trial demonstrates improved skin conditions and sleep following daily emollient application in infants and children having dry skin and being at risk of AD. Especially parents of infants showed a reduced fear that their children might develop AD. Further studies are required to investigate the preventive effect of daily emollient therapy in this special cohort evaluating the outcome measures used in this trial.

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“…Skin desquamation increases as skin hydration decreases [31] [32] [33]. Cheek skin translucency was also decreased after the period of sleep deprivation.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Sleep Deprivation on the Biophysical Properties of Facial Skin

Kim¹,

Kim²,

Kang³

et al. 2017

JCDSA

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Lack of sleep is a problem in today's society, and many people are concerned about changes in their outward appearance due to lack of sleep. People generally come up with some noticeable skin attributes as symptoms of sleep deficiency including rough, dull, and dry skin as well as droopy eyelids and dark eye circles. Several previous reports also suggested that poor sleep could affect the skin condition. The purpose of this study was to evaluate the effect of one night of sleep deprivation on various skin biophysical properties. Twenty four healthy females participated in a study of one night of sleep deprivation. Subjects were kept awake for one night in a laboratory with controlled temperature and relative humidity. The skin condition of each subject was evaluated after normal sleep pattern and after one night of sleep deprivation. The measured skin biophysical parameters included transepidermal water loss, facial pore size, and skin tone, hydration, elasticity, desquamation, translucency, and blood flow. The cheek, eye, and lip areas were evaluated. After one night of sleep deprivation, multiple skin biophysical parameters showed changes when compared to the baseline measurements. A significant decrease in skin hydration and impaired barrier function were observed (p < 0.05). Decreased hydration led to decreased skin elasticity and translucency and increased skin scaling (p < 0.05). Facial pores were more conspicuous, and skin lightness decreased significantly (p < 0.05). Furthermore, skin blood flow decreased prominently (p < 0.05). The results demonstrated that the skin features that are recognized as symptoms of sleep deficiency actually showed remarkable differences after a period of sleep deprivation, and some of these features were confirmed in the eye, lip, as well as the cheek areas. This study revealed a significant association between sleep deprivation and skin biophysical properties by scientific measuring.

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The management of dry skin with topical emollients – recent perspectives

Cited by 92 publications

References 33 publications

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Children with Dry Skin and Atopic Predisposition: Outcome Measurement with Validated Scores for Atopic Dermatitis

The Effects of Sleep Deprivation on the Biophysical Properties of Facial Skin

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