“…Thus, the use of structured side effect rating scales has not been particularly widespread in antidepressant drug trials. One of the first to be used in such trials was a 22-item side effect scale described by Waldron and Bates (7) and used by them in a comparison between imipramine and desipramine. The scale included, La., the following symptoms: dry mouth, blurred vision, sweating, tremor, syncopal attacks, rash, headache, palpitations, dizziness, flushing, constipation, overactivity, anxiety, nausea, general weakness, and tinnitus.…”