The Management of Cardiovascular Risk through Epigenetic Biomarkers

Metzinger, Laurent; Franciscis, Stefano de; Serra, Raffaele

doi:10.1155/2017/9158572

Cited by 18 publications

(20 citation statements)

References 51 publications

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“…Three main epigenetic processes are represented by DNA methylation, posttranslational histone modifications, and RNA-based mechanisms [ 13 ]. Dysregulated epigenetic modifications may lead to irregular development of disease.…”

Section: Discussionmentioning

confidence: 99%

Altered DNA Methylation of Long Noncoding RNA uc.167 Inhibits Cell Differentiation in Heart Development

Yin

Feng

Cheng

et al. 2018

BioMed Research International

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In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations. Methylated DNA immunoprecipitation (MeDIP) was performed to examine the differences in methylation status of overexpressed uc.167 in P19 cells. GO and KEGG pathway analyses of differentially methylated genes were also conducted. We found that the distribution of differentially methylated regions (DMRs) peaks in different components of genome was mainly located in intergenic regions and intron. The biological process associated with uc.167 was focal adhesion and Rap1 signaling pathway. MEF2C was significantly decreased in uc.167 overexpressed group, suggesting that uc.167 may influence the P19 differentiation through MEF2C reduction. Taken together, our findings revealed that the effect of uc.167 on P19 differentiation may be attributed to the altered methylation of specific genes.

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Section: Discussionmentioning

confidence: 99%

Altered DNA Methylation of Long Noncoding RNA uc.167 Inhibits Cell Differentiation in Heart Development

Yin

Feng

Cheng

et al. 2018

BioMed Research International

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“…30 DNA methylation is associated with transcriptional repression, and it has been implicated in different cardiovascular diseases, such as atherosclerosis, coronary heart disease, and abdominal aortic aneurysm. 30 Epigenetic therapies…”

Section: Epigenetics and Aicmentioning

confidence: 99%

Epigenetic Changes Associated With Anthracycline‐Induced Cardiotoxicity

Tantawy

Pamittan

Singh

et al. 2020

Clinical Translational Sci

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Advances in cancer treatment have significantly improved the survival of patients with cancer, but, unfortunately, many of these treatments also have long‐term complications. Cancer treatment‐related cardiotoxicities are becoming a significant clinical problem that a new discipline, Cardio‐Oncology, was established to advance the cardiovascular care of patients with growing cancer populations. Anthracyclines are a class of chemotherapeutic agents used to treat many cancers in adults and children. Their clinical use is limited by anthracycline‐induced cardiotoxicity (AIC), which can lead to heart failure. Early‐onset cardiotoxicity appears within a year of treatment, whereas late‐onset cardiotoxicity occurs > 1 year and even up to decades after treatment completion. The pathophysiology of AIC was hypothesized to be caused by generation of reactive oxygen species that lead to lipid peroxidation, defective mitochondrial biogenesis, and DNA damage of the cardiomyocytes. The accumulation of anthracycline metabolites was also proposed to cause mitochondrial damage and the induction of cardiac cell apoptosis, which induces arrhythmias, contractile dysfunction, and cardiomyocyte death. This paper will provide a general overview of cardiotoxicity focusing on the effect of anthracyclines and their epigenetic molecular mechanisms on cardiotoxicity.

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“…Epigenetic modifications detection could successfully be translated as biomarkers into clinical medicine, since it provides insight into functioning of genes and explains phenotypic differences between healthy and diseased individuals. The epigenetic modifications could also be used as biomarkers for determination of environmental factors affecting health and disease onset, and also as diagnostic and prognostic biomarkers in oncology, endocrinology, cardiology, and neuropsychiatry (GARCÍA-GIMÉNEZ, et al 2017;METZINGER, et al 2017;SANDOVAL, et al 2013).…”

Section: Future Clinical Applications Of Epigeneticsmentioning

confidence: 99%

Epigenetics in disease etiopathogenesis

Glavaški

Stankov

2019

Genetika

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2019): Epigenetics in disease etiopathogenesis.-Genetika, Vol 51, No.3, 975-994. The term epigenetics refers to heritable changes in gene expression that are not caused by modifications in DNA sequence. Epigenetic changes are DNA methylation, histone modifications, nucleosome positioning, and non-coding RNA (including microRNA) mediated modifications. Epigenetic mechanisms are involved in malignant diseases, imprinting defects, and some hereditary diseases. Recent research explained the role of epigenetic disorders in infections, autoimmune, neurodegenerative and bone diseases, as well as in psoriasis, endometriosis, and polycystic ovary syndrome. Epigenetic modifications have a potential clinical application as diagnostic and prognostic biomarkers, and also as therapeutic targets in oncology, endocrinology, cardiology, and neuropsychiatry. Stress, anxiety, depression, emotions and many other psychological factors may affect epigenetic mechanisms. Influence of preconception parental stress exposure transmits to the next generation through epigenetic changes, as direct results of prenatal and postnatal environmental factors. Epigenetic changes identify environmental factors which affect health and cause disease onset. Milk is the sophisticated system of communication between mother and infant, operating via epigenetic mechanisms. Lifelong consumption of bovine milk causes epigenetic disorders. Recent studies provide important information about the role of bioactive dietary nutrients which modify DE SARIO, A. (2009): Clinical and molecular overview of inherited disorders resulting from epigenomic dysregulation. Eur. J. Med. Genet., 52(6): 363-372.

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The Management of Cardiovascular Risk through Epigenetic Biomarkers

Cited by 18 publications

References 51 publications

Altered DNA Methylation of Long Noncoding RNA uc.167 Inhibits Cell Differentiation in Heart Development

Altered DNA Methylation of Long Noncoding RNA uc.167 Inhibits Cell Differentiation in Heart Development

Epigenetic Changes Associated With Anthracycline‐Induced Cardiotoxicity

Epigenetics in disease etiopathogenesis

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