The management of allergic eye diseases in primary eye care

Chigbu, DeGaulle I.

doi:10.1016/j.clae.2009.08.002

Cited by 28 publications

(16 citation statements)

References 74 publications

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“…Allergic reaction of the eyes due to contact with external allergens causes conjunctival injection, follicular conjunctivitis, periorbital edema, and pruritus [7]. The signs that the patient in our case showed are consistent with an allergic reaction, considering that he suffered from conjunctival injection, conjunctival follicles, and periorbital edema.…”

Section: Discussionsupporting

confidence: 53%

Severe edema of the eyes and lips as rare side effects of eye ointment for protection of eyes under general anesthesia -A case report-

Park

Kim

2012

Korean J Anesthesiol

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Patients undergoing non-ocular surgery under general anesthesia may suffer from ocular complications because of the loss of protective reflexes. Simple taping of the eyelids closed, the instillation of ointments into the conjunctival sac, and the use of protective goggles have been recommended for eye protection. We observed a case of a 6-year-old child undergoing tonsillectomy and adenoidectomy who experienced severe edema after application of an ointment (Terramycin ophthalmic ointment) to the orbits and upper lip. After several days of steroid and antihistamine administration, the edema of the orbits and lip returned to normal. Therefore, we suggest that unexpected edema in the orbits and lip following surgery can be due to hypersensitivity to the ointment.

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Section: Discussionsupporting

confidence: 53%

Severe edema of the eyes and lips as rare side effects of eye ointment for protection of eyes under general anesthesia -A case report-

Park

Kim

2012

Korean J Anesthesiol

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“…atopic and vernal keratoconjunctivitis (AKC and VKC)). SAC occurs seasonally and is elicited by grass, trees, and weed pollens, while PAC occurs year round due to allergens such as dust mites and animal dander (1, 2). AKC and VKC can cause severe damage to the ocular surface, leading to corneal scarring and vision loss (3, 4).…”

Section: Introductionmentioning

confidence: 99%

T helper subsets in allergic eye disease

Reyes

Saban²

2014

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Ocular allergy is an IgE-mediated disease that results in inflammation of the conjunctiva and, in more severe cases, the cornea. This is driven by an immediate hypersensitivity response via mast cells, followed by a late phase response mediated by eosinophils—both of which are indeed dependent on T helper (Th) lymphocyte activity. Here we provide an update on Th subsets (Th1, Th2, Th17, T regulatory (Treg) and their relevance in ocular allergy. Recent findings Recent evidence in ocular allergy points to an involvement of other Th subsets, in addition to Th2. However, how these subsets are respectively activated and their role in mediating the different clinical forms is poorly understood. Novel mouse models may facilitate addressing such unknowns, and future challenges will involve how to translate such findings into more effective and “patho-specific” treatments. Summary Ocular allergy, especially in severe forms, involves subsets other than Th2. Th1 cells have been detected in mild and severe forms, and recent evidence points to a possible role for IL-17 in severe disease. Tregs, on the other hand, dampen pathogenic Th cell function and allergy immunotherapy is associated with Treg augmentation in disease management. Further understanding of Th biology is warranted and may lead to better therapies.

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“…21 In contact dermatoconjunctivitis, a pure type IV hypersensitivity reaction occurs, which accounts for its poor response to topical antihistamines and mast cell stabilisers. 22 • Topical and oral steroids and immunomodulatory agents should be prescribed only under the care of an ophthalmologist in refractory cases Giant papillary conjunctivitis is caused by both allergy and mechanical irritation triggered by a foreign material such as contact lenses, ocular prostheses, or exposed sutures. 19 Subtarsal papillary hypertrophy is seen with a mucous discharge that remits with removal of the offending agent.…”

Section: Rarer Causesmentioning

confidence: 99%