The mammosphere-derived epithelial cell secretome modulates neutrophil functions in the bovine model
Rebecca M. Harman,
Anja Sipka,
Kelly A. Oxford
et al.
Abstract:BackgroundInnovative therapies against bacterial infections are needed. One approach is to focus on host-directed immunotherapy (HDT), with treatments that exploit natural processes of the host immune system. The goals of this type of therapy are to stimulate protective immunity while minimizing inflammation-induced tissue damage. We use non-traditional large animal models to explore the potential of the mammosphere-derived epithelial cell (MDEC) secretome, consisting of all bioactive factors released by the c… Show more
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