Abstract:The most frequent cause of malabsorption syndrome (MAS) in developed countries is the celiac disease (CD). There are two possible approaches for exact diagnostic of this disorder: in case of full blown clinical symptoms the golden standard is duodenal biopsy. When it shows classical mucosa lesions (Marsh type 3 mucosa atrophy of various grades), the diagnosis of CD is confirmed. However, if intraepithelial lymphocyte infiltration (IEL) and/or hyperplastic crypts can be seen in the absence of mucosa atrophy (Ma… Show more
“…Most patients with TS had mild to moderate villous abnormalities (42.3% and 45.8%, respectively), in comparison with only 11.8% mild to moderate villous abnormalities in CD . While crypt hyperplasia was identified as a dependable of mucosal change in CD, patients with TS were reported to have hypoplastic mucosal crypts …”
Both patients with CD and TS have overlapping clinical, endoscopic, and histological characteristics, and there is no single diagnostic feature for differentiating CD from TS except for celiac specific serological tests.
“…Most patients with TS had mild to moderate villous abnormalities (42.3% and 45.8%, respectively), in comparison with only 11.8% mild to moderate villous abnormalities in CD . While crypt hyperplasia was identified as a dependable of mucosal change in CD, patients with TS were reported to have hypoplastic mucosal crypts …”
Both patients with CD and TS have overlapping clinical, endoscopic, and histological characteristics, and there is no single diagnostic feature for differentiating CD from TS except for celiac specific serological tests.
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