The major risk factor for depression in the Chinese middle-aged and elderly population: A cross-sectional study

Ni, Xiaolin; Su, Huabin; Lv, Yuan; Chen, Chen; Zhang, Di; Chen, Qing; Zhang, Shenqi; Yang, Ze; Sun, Liang; Zhou, Qian; Zhu, Xiaoquan; Gao, Danni; Fang, Sihang; Hu, Caiyou; Pang, Guofang; Yuan, Huiping

doi:10.3389/fpsyt.2022.986389

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…In older age, Blazer et al conducted a study in the United States and found that the prevalence of depression tended to decrease with age, although it remained a significant concern, particularly in the context of other physical and mental health conditions that are more common in older age [ 11 ]. Another study conducted in China found that depression in older adults was often accompanied by cognitive and physical symptoms, such as memory problems and fatigue, and may be more difficult to diagnose and treat due to overlapping symptoms with other conditions [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Unraveling Depressive Symptomatology and Risk Factors in a Changing World

Sousa

Henriques

Almeida

et al. 2023

IJERPH

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Background: This study aimed to examine the prevalence and factors associated with symptoms of depression during the third wave of the COVID-19 pandemic. Methods: A representative sample of Portuguese adults was included in this populational survey, conducted between 25 March and 31 July 2021, with participants completing a structured questionnaire via phone interview. The symptoms of depression were measured using the Portuguese version of the Hospital Anxiety and Depression Scale (HADS). Multivariate logistic regression analyses were used to examine the association between sociodemographic, health, and lifestyle factors and depression levels (normal, mild, or moderate/severe). Results: The estimated prevalence of depression symptoms among participants was 24%. Participants who were women, were in older age groups, had multimorbidity, lived in isolated Portuguese regions such as islands and Alentejo, and were retired or unemployed more frequently reported depression symptoms. Economic hardship was also found to be associated with an increased frequency of mild or moderate-to-severe depression. In contrast, higher levels of education, regular alcohol intake, and regular exercise were associated with a lower frequency of depression symptoms. Conclusions: These findings highlight that during the third wave of the COVID-19 pandemic, a high proportion of Portuguese adults reported depression symptoms, particularly the COVID-19-vulnerable strata such seniors, patients with multimorbidity, and people in economic hardship. On the other hand, citizens who performed regular physical exercise reported lower depressive symptomology. Our work contributes to improving the planning of mental health promotion after the COVID-19 pandemic and future emergencies.

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Section: Discussionmentioning

confidence: 99%

Unraveling Depressive Symptomatology and Risk Factors in a Changing World

Sousa

Henriques

Almeida

et al. 2023

IJERPH

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“…Depression is one of the most common mental disorders, affecting nearly 3.8% of the global population [5] , and is a major contributor to the global burden of disease and a leading cause of disability, and is an important public health problem worldwide.In China, a national survey reported that about 30% of men and 43% of women aged 45 and older experienced depressive symptoms [6] .Many studies have demonstrated that ACEs function in the life course on depression susceptibility [7][8] . With the accelerated population aging, understanding the factors and the underlying mechanisms that may increase the risk of depression in middle-aged and older adults has become an important public health priority.…”

Section: Introductionmentioning

confidence: 99%

Adverse childhood experiences、marital status and depressive symptoms in later life among the middle-aged and elderly Chinese adults : the mediating role of marital status

Yu,

Wang,

Liu

et al. 2024

Preprint

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Background Many studies have shown that adverse childhood experiences (ACEs) lead to adverse social relations in middle-aged and elderly people and harm physical and mental health, but few studies have focused on the impact of ACEs on marital status in middle-aged and elderly people and the potential influence of marital status between ACEs and depressive symptoms. Purpose This study aimed to analyze the effect of ACEs on marital status and depressive symptoms in the middle-aged and elderly Chinese population, and to explore the mediating role of marital status in the association between ACEs and depressive symptoms in middle-aged and older adults. Method This study used the China Health and Retirement Longitudinal Study (CHARLS) 2014 life history survey and 2015 and 2018 follow-up data to analyze,ten ACEs conditions and marital status were collected by questionnaire,using the Center for Epidemiological Studies Depression Scale (CESD-10) 10-item short form to assess depressive symptoms. The association between cumulative ACEs and marital status was assessed by constructing a multinomial logistic regression (MLR) model, as well as a binary logistic regression model to assess the association between ACEs and depressive symptoms. The mediating role of marital status in the association between ACEs and depressive symptoms was also assessed. Results A total of 10,246 individuals aged 45 years or older were included in the analysis. Compared to individuals who did not experience ACEs, those who experienced two or more ACEs had a higher risk of being unmarried (divorced/never married) (OR = 1.67, 95% CI=[1.10,2.51]) and a higher risk of depressive symptoms (OR = 1.66, 95% CI=[1.49,1.84]) in middle and old age.There was a significant dose-response relationship between cumulative ACEs counts and both divorce/unmarried and depressive symptoms. Unmarried status partially mediated the association of ACEs with depressive symptoms. Conclusion Chinese middle-aged and older people who experienced two or more ACEs have higher risks of unmarried status and depressive symptoms, and unmarried status partially mediated the ACEs-depressive symptom association. These findings reveal the fact that we need to develop life-cycle public health strategies to reduce exposure to ACEs and improve the marital status of middle-aged people, thereby reducing the risk of depression among middle-aged and older adults in China.

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“…A significant proportion of older adults will suffer from one or more age-related diseases, including two significant conditions that can cause high morbidity and disability, with high economic burden consequences: stroke (1) and depression (2). Stroke is divided into ischemic stroke and hemorrhagic stroke.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms associated with post-stroke depression and pharmacologic therapy

Zhan,

Kong

2023

Front. Neurol.

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Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD. Neuroinflammation, neuroendocrinology, neurotrophic factors, and the site of the stroke lesion may affect neurotransmitters. Thus the mechanisms of PSD have been increasingly studied. Pharmacological treatment mainly includes SSRIs, noradrenergic and specific serotonergic antidepressant (NaSSA), anti-inflammatory drugs, vitamin D, ect, which have been confirmed to have better efficacy by clinical studies. Currently, there is an increasing number of studies related to the mechanisms of PSD. However, the mechanisms and pharmacologic treatment of PSD is still unclear. In the future, in-depth research on the mechanisms and treatment of PSD is needed to provide a reference for the prevention and treatment of clinical PSD.

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The major risk factor for depression in the Chinese middle-aged and elderly population: A cross-sectional study

Cited by 7 publications

References 44 publications

Unraveling Depressive Symptomatology and Risk Factors in a Changing World

Unraveling Depressive Symptomatology and Risk Factors in a Changing World

Adverse childhood experiences、marital status and depressive symptoms in later life among the middle-aged and elderly Chinese adults : the mediating role of marital status

Mechanisms associated with post-stroke depression and pharmacologic therapy

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