The Major Histocompatibility System of the Chicken

Hála, K

doi:10.1007/978-3-642-95293-7_9

Cited by 29 publications

(12 citation statements)

References 73 publications

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“…The most extensive study was made by Hala andco-workers (1976, 1981a), who analysed 10,252 animals and fovnd four recombinants. These recombinations involved the haplotypes B4, B", and B7 and the recombinant haplotypes are named B4r1, BIZr', and B4*' (the fourth recombinant turned out to be identical to B4") (HBla et al 1981a).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, however, little is known about MHC in non-mammalian vertebrates. Only birds (chickens (Hala 1977)) and toads (Xenopus laevis (Du Pasquier & Kobe1 1979)) have so far provided us with some information on MHC, and only in the chicken are there as yet any data available to prove the existence of both Class I and Class I1 structures. In comparison with mammals, the chicken displays a unique class of MHC structure represented by B-G (Hala 1977, Simonsen 1981.…”

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confidence: 99%

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New recombinants within the MHC (B‐complex) of the chicken

Koch

Skjødt

Toivanen³

et al. 1983

Tissue Antigens

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In a search for genetic recombinations within the major histocompatibility complex (MHC) of the chicken, the B‐complex, the offspring from matings between heterozygous B15/B21 and B4/B6 animals were analysed by red cell agglutination. Among the progeny, 8,912 informative typings were performed. Four recombinants were found, all separating the B‐complex loci B‐F and B‐G (B‐F codes for Class I antigens, B‐G codes for an antigen of which there is no known homologue in mammals). B‐L (Class II antigen) always followed B‐F. Stimulation in graft versus host reactions and in mixed lymphocyte cultures followed B‐F/B‐L. The mapping distance between the two loci B‐F and B‐G is in the range of 0.04 centimorgan. The lack of recombinants separating individual B‐F loci in this study and in the studies of others might indicate that chicken MHC is less complex than those of mammalian species, but alternative explanations are also possible. So far no serologically defined recombinant separating Class I (B‐F) and Class II (B‐L) loci has been found.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

New recombinants within the MHC (B‐complex) of the chicken

Koch

Skjødt

Toivanen³

et al. 1983

Tissue Antigens

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“…Chickens [24] based on the internationally accepted nomenclature [25]. In all experimental groups both female and male animals were represented proportionally (and none of the parameters investigated during this study differed between female and male birds).…”

Section: Animalsmentioning

confidence: 99%

“…This band was found in the DNA of all female and male 0s chickens of the three sublines homozygous for the B', B13 or B'' MHC alleles, in a few individuals of the close-bred Cornell C-strain (CS, I l l 3 ) , the mother strain of the OS, and in none of the three highly inbred strains GB-1 (B13), CC (It4), and CB (Ill2) [4,51. The latter strain is unrelated to the OS, expresses an MHC type not associated with SAT, and behaves "normally" in most immunological characteristics, i. e. similar to outbred NWL chickens [24]. For these reasons we decided to investigate the parameters listed above in crosses of the CB strain with chickens of the well reproducing OS-Bi5Bi5 subline.…”

Section: Cn-inducing Effect Of Cytokine Preparations Is Transmitted Tomentioning

confidence: 99%

Genetic Analysis of Extrathyroidal Features of Obese Strain (Os) Chickens With Spontaneous Autoimmune Thyroiditis

Kroemer¹,

Faessler²,

Hála³

et al. 1988

Eur J Immunol

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The Obese strain (OS) of chickens, which is afflicted with Hashimoto-like spontaneous autoimmune thyroiditis (SAT), displays elevated T cell proliferation, interleukin (IL)2 production and IL2 receptor expression upon mitogen stimulation, and defects in the neuroendocrine control of the immune system including elevated corticosteroid-binding globulin (CBG) and a deficient increase of serum corticosterone (CN) upon cytokine injection. Recently this strain has further been shown to harbor retrovirus-related sequences (endogenous virus no. 22, ev22) absent in healthy control strains. To determine the number of genes responsible for SAT-associated immunodysregulation and to unravel possible ev22 associations, we analyzed the above immune and endocrine parameters in F1 hybrids and backcrosses of the autoimmune OS B15B15 with healthy inbred CB B12B12 chickens. OS-like T cell hyperproliferation and IL2 hypersecretion in response to both concanavalin A and phytohemagglutinin were transmitted as autosomal dominant traits and co-segregated in backcross animals. In vivo hyporesponse of the OS to the corticosterone-inducing effect of cytokine preparations was inherited dominantly and the elevated CBG serum levels recessively. None of these traits appeared to be major histocompatibility complex (MHC) linked. However, while T cell abnormalities and elevated CBG serum levels were not associated with the autosomal ev22 locus, in vivo hyporesponsiveness to glucocortocoid-inducing cytokines co-segregated with this OS-specific provirus. These results add to the concept of SAT as a polyetiological and plurigenetic disease and do not support our previous hypothesis that T cell hyperreactivity and immunoendocrine dysfunction might be functionally related.

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“…The chicken MHC, the B complex (Pazderka et al 1975, Hala 1977, Simonsen 1981, determines products belonging to at least the two former classes. F antigens are expressed in all nucleated cells and belong to class I.…”

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The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions

1982

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The F antigens, which are serologically defined Class I gene products of the major histocompatibility complex in chickens (the B complex), were analysed in outbred birds. Private specificities of the F13 antigen from the inbred CC strain were detected in 20 outbred chickens by a haemagglutination technique. In the GVH-inhibition-release test F13 antigens from outbred and inbred chickens were identical.The L antigens, which are the Class I1 antigens of the B complex, were detected with specific anti L13 alloantisera by indirect immunofluorescence. Antisera defining the L13 antigen(s) of the inbred C C line reacted with all F13 positive outbreds. As a test of one-way direct compatibility of the inbred and outbred animals typing F13, graft versus host reactions were performed, injecting blood of F13 positive outbreds into inbred B'3''3 cggs. N o GVH stimulation attributable to MHC determinants was found. In MLR, responder cells from outbred M H C heterozygous chickens, which typed F13/x, were stimulated by inbred F13113 homozygous typing cells, and weak, but significant, reactions were found. Further analysis in the accompanying paper, however, revealed no difference in the lymphocyte activating determinants (Lads) of inbred and outbred birds typing F13 and L13. No individual has yet been found which carries one of these antigens in the absence of the other.List of abbreviations: B = The complex of linked genes constituting the @ 1982 Munksgaard, Copenhagen

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The Major Histocompatibility System of the Chicken

Cited by 29 publications

References 73 publications

New recombinants within the MHC (B‐complex) of the chicken

New recombinants within the MHC (B‐complex) of the chicken

Genetic Analysis of Extrathyroidal Features of Obese Strain (Os) Chickens With Spontaneous Autoimmune Thyroiditis

The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions

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The Major Histocompatibility System of the Chicken

Cited by 29 publications

References 73 publications

New recombinants within the MHC (B‐complex) of the chicken

New recombinants within the MHC (B‐complex) of the chicken

Genetic Analysis of Extrathyroidal Features of Obese Strain (Os) Chickens With Spontaneous Autoimmune Thyroiditis

The major histocoinpatibility complex of outbred chickens: I. Analysis of the B13 haplotype by serology and cellular reactions

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The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions