The major histocompatibility complex of the rat (Rattus norvegicus)

Günther, Eberhard; Walter, Lutz

doi:10.1007/s002510100361

Cited by 109 publications

(89 citation statements)

References 169 publications

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“…6, A and B). LEW and F344 rats are genetically identical in RT1.A and RT1.B/D (classical class I and class II MHC) genes, but differ in RT1.C/E/M regions of the rat MHC (41,42). If Ly-49G BALB/c recognizes a rat MHC ligand, then a nonclassical molecule encoded in the RT1.C/ E/M region of the RT1 1 haplotype may be a ligand.…”

Section: Discussionmentioning

confidence: 99%

Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands

Silver

Lavender

Gong

et al. 2002

The Journal of Immunology

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The Ly-49 multigene receptor family regulates mouse NK cell functions. A number of Ly-49 genes exhibit allelic variation, but the functional significance of allelic differences in extracellular domains of Ly-49 receptors regarding ligand specificity is largely unknown. Amino acid differences exist in the extracellular domains of the B6 and BALB/c allele products of the inhibitory Ly-49G receptor. We constructed chimeric Ly-49 receptors consisting of common cytoplasmic and transmembrane regions of the activating Ly-49W receptor fused with the ectodomains of the B6 and BALB/c alleles of Ly-49G. Expression of these chimeras in the RNK-16 rat NK cell line allowed us to study the specificity of inhibitory receptor ectodomains as they stimulated NK lytic activity. We found that the ectodomain of the BALB/c allele of Ly-49G recognizes both H-2Dd and Dk class I MHC alleles, whereas the ectodomain of the B6 allele of Ly-49G recognizes Dd, and not Dk. The specificity for Dk as well as Dd of the wild-type Ly-49GBALB/c allele product was confirmed with RNK-16 transfectants of this inhibitory receptor. Furthermore, the ectodomain of the Ly-49GBALB/c allele recognizes a distinct repertoire of xenogeneic ligands that only partially overlaps with that recognized by Ly-49GB6. Our results indicate that allelic variation in Ly-49 extracellular domains can have functional significance by altering Ly-49 receptor specificity for mouse class I MHC and xenogeneic ligands.

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Section: Discussionmentioning

confidence: 99%

Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands

Silver

Lavender

Gong

et al. 2002

The Journal of Immunology

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“…The genetic architecture of the MHC has been detailed for several model vertebrate species, most notably in humans (termed HLA; MHC Sequencing Consortium, 1999), mouse (H-2; Younger et al, 2000), rat (RT-1; Gunther and Walter, 2001;Hurt et al, 2004) and chicken (B-locus; Kaufman et al, 1999). There are similarities across these model systems in MHC structure, in that the class I and class II genes are linked together in a single gene complex in each case (Hughes and Yeager, 1998;Hess and Edwards, 2002).…”

Section: The Structure and Function Of The Mhcmentioning

confidence: 99%

The evolutionary ecology of the major histocompatibility complex

2005

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The major histocompatibility complex (MHC) has become a paradigm for how selection can act to maintain adaptively important genetic diversity in natural populations. Here, we review the contribution of studies on the MHC in non-model species to our understanding of how selection affects MHC diversity, emphasising how ecological and ethological processes influence the tempo and mode of evolution at the MHC, and conversely, how variability at the MHC affects individual fitness, population dynamics and viability. We focus on three main areas: the types of information that have been used to detect the action of selection on MHC genes; the relative contributions of parasite-mediated and sexual selection on the maintenance of MHC diversity; and possible future lines of research that may help resolve some of the unanswered issues associated with MHC evolution.

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“…The better purified myoblasts led to an augmentation of transplantation efficiency (Qu and Huard 2000). Günther and Walter (2001) found that highly purified MDSCs expressing both type I and type II major histocompatibility complex could completely avoid rapid cell death after transplantation, indicating that purification of MDSCs can prevent immune rejection. The proportion of MDSCs in skeletal muscle cells is low, approximately 1-5 % (Kuang et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Biological characteristics of muscle-derived satellite cells isolated from rats at different postnatal days

Ren

Wang

et al. 2015

Cytotechnology

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This study investigated the in vitro growth characteristics and differential potential of musclederived satellite cells (MDSCs) derived from rats at different postnatal (P) stages, in order to expand the range of source material for tissue engineering. Rat MDSCs were isolated from P5, P10, P15, P21 and P42 rat skeletal muscles using double enzyme digestion and differential adherent culture. Neurogenic, osteogenic and myogenic induction media were used to induce directed differentiation. Differentiated nerve cells, osteoblasts and myotubes were identified by their morphology and immunohistochemical staining. Most cells transformed into spindle-shaped mononuclear cells after 48 h and proliferated rapidly. MDSCs were difficult to isolate from P42 rats. After neurogenesis, four groups MDSCs formed neuron-specific enolase positive polygonal-shaped dendritic cells. After osteogenesis, P5, P10, P15 and P21 MDSCs formed Alizarin red-and osteocalcin-positive bone nodules. After myogenesis, myotubes were formed and were fast muscle myosin-positive. MDSCs derived from P5, P10, P15 and P21 rat skeletal muscle are easy to isolate, culture and amplify in vitro, which increases the range of source material available for tissue engineering.

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The major histocompatibility complex of the rat (Rattus norvegicus)

Cited by 109 publications

References 169 publications

Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands

Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands

The evolutionary ecology of the major histocompatibility complex

Biological characteristics of muscle-derived satellite cells isolated from rats at different postnatal days

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