The major bioactive components of seaweeds and their mosquitocidal potential

Abstract

Seaweeds are one of the most widely studied natural resources for their biological activities. Novel seaweed compounds with unique chemical structures have been reported for their pharmacological properties. The urge to search for novel insecticidal compound with a new mode of action for development of botanical insecticides supports the relevant scientific research on discovering the bioactive compounds in seaweeds. The mosquitocidal potential of seaweed extracts and their isolated compounds are documented in this review paper, along with the discussion on bioactivities of the major components of seaweeds such as polysaccharides, phenolics, proteins, terpenes, lipids, and halogenated compounds. The effects of seaweed extracts and compounds toward different life stages of mosquito (egg, larva, pupa, and adult), its growth, development, and reproduction are elaborated. The structure-activity relationships of mosquitocidal compounds are discussed to extrapolate the possible chemical characteristics of seaweed compounds responsible for insecticidal properties. Furthermore, the possible target sites and mode of actions of the mosquitocidal seaweed compounds are included in this paper. The potential synergistic effects between seaweeds and commercial insecticides as well as the toxic effects of seaweed extracts and compounds toward other insects and non-target organisms in the same habitat are also described. On top of that, various factors that influence the mosquitocidal potential of seaweeds, such as abiotic and biotic variables, sample preparation, test procedures, and considerations for a precise experimental design are discussed. The potential of active seaweed extracts and compounds in the development of effective bioinsecticide are also discussed.

Structural characterization and evaluation of mosquito-larvicidal property of silver nanoparticles synthesized from the seaweed, Turbinaria ornata (Turner) J. Agardh 1848

“…The zeta potential value of To-AgNPs is an indication of repulsive force which could be used to predict the long term stability of the product . Several researchers have found that the seaweeds possess good insecticidal property like that of the terrestrial plantsderived bio-insecticides (Ghosh et al 2012, Oliveira et al 2010, Yu et al 2014. Presently, we have investigated the larvicidal effect of T. ornata on the fourth instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus.…”

Larvicidal Potential of the Halogenated Sesquiterpene (+)-Obtusol, Isolated from the Alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the Dengue Vector Mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae)

“…Our results suggest that the midgut is an important site of action of (+)-obtusol and the increased level of ROS could contribute to larval mortality. This is the first time that morphological and physiological effects have been shown in larvae treated with a seaweed-derived molecule, as previously only physiological effects of compounds derived from terrestrial plants have been described [ 39 , 57 , 58 , 59 ]. The data here sheds some light on the site of action of these molecules, which could be investigated as models for design of more efficient vector control agents.…”

“…Additionally, the present work corroborated previous reports suggesting that seaweeds are very important sources of insecticides, since they produce bioactive compounds with higher potency than many terrestrial organisms. It is worth mentioning that L. dendroidea crude extract from Vermelha beach was more potent in comparison to many of the previously investigated seaweed extracts [ 39 , 60 , 61 , 62 ]. It is important to evaluate strategies for utilizing seaweed-derived metabolites to control disease vectors such as A. aegypti .…”

“…Because of their effectiveness against mosquitoes and lack of deleterious effects on the environment, seaweed bioactive compounds are promising models for new synthetic insecticides. Previous studies reported that seaweed-derived compounds displayed insecticidal activity, especially against larval stages of Culex pipiens pallens Coquillett [ 35 , 36 , 37 , 38 , 39 ]. Recently, extracts of seaweeds from the northwest coast of Brazil were shown to present larvicidal activity against A. aegypti [ 40 ].…”

불등풀가사리 다당류의 분자량에 따른 면역증강 효과

“…Marine algae, also known as seaweed or macroalgae, are photosynthetic eukaryotic organisms that can be found in coastal areas. There are three main seaweed taxa that are classified based on their pigmentation: red algae, green algae, and brown algae (1 Gloiopeltis furcata (G. furcata) is a red alga belonging to the genus Gloiopeltis of the Endocladiaceae family, that been widely used in traditional herbal medicine, and as a food thickener (7). Polysaccharides with different physiological activities (antitumor, antiviral, anti-inflammatory) have been found in water and ethanol extracts prepared from G. furcata (8,9).…”