The Main Risk Factors for Inflammatory Periodontal Disease in Young People

Kovách, I; Aljeksjejenko, N.V.; Zelins'kyj, A.L.

doi:10.35220/2078-8916-2019-32-2-65-68

Cited by 4 publications

(2 citation statements)

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“…(2019), из 286 человек от возраста 18 -30 лет, у кого наблюдались хронический катаральный гингивит оценка гигиены полости рта варьировалась от «удовлетворительного» до «плохого». Авторы акцентировали на внимание этот фактор и сделали вывод о профилактике заболеваний пародонта для предотвращения ухудшения для молодёжи статуса стоматологического здоровья [62].…”

Section: Introductionunclassified

Review the status of dental health and oral hygiene for young adult in Vietnam and in some countries

Anh

Shevelyuk

2022

Èndodontiâ today

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At the age of 18 to 25, independent life begins, when most young people face the first difficulties of life, and in this age the issue of caring for oral hygiene fades into the background.Review the literature to identify the overall status of dental health and oral hygiene for young adult in Vietnam between other countries. Research results: Articles analyzed based on Pubmed, Medline, Web of Science, Scopus and Embase platforms (Key words: young adult, oral health status, decay, periodont; Numbers Russian research: 35, numbers foreigner research: 32). In some countries, insufficient attention has yet been paid to the status of dental health and the state of oral hygiene among young adult in the age group from 18 to 25 years. To prevent the deterioration of the dental health of the general population as a whole, measures of sanitary and educational work are needed, as well as constant monitoring of the state of dental health among young adult. Poor oral hygiene can lead to the development of carious and periodontal diseases among young adult.

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Section: Introductionunclassified

Review the status of dental health and oral hygiene for young adult in Vietnam and in some countries

Anh

Shevelyuk

2022

Èndodontiâ today

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“…An important problem of modern dentistry remains the disease of periodontal tissues, in particular generalized periodontitis, which, according to the results of epidemiological studies, affects from 92 to 98 % over the age of 40 of the population of different regions of Ukraine [1,9,12]. Unfortunately, the risk factors for the occurrence of inflammatory diseases increase every year, not only in the elderly, but also in young people [3,4,6]. The activation of lipid peroxidation processes is a universal mechanism of tissue stress damage.…”

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The assessment of the status of the prooxidant-antioxidant system in patients with chronic generalized periodontitis in the post-сovid period

Matviykiv,

Rozhko,

Tokaryk

2022

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Resume. The article presents the results of the study of the intensity of free radical processes (FRP) and the activity of antioxidant systems (AOS) in the blood serum of people who were infected with the Sars-Cov-2 virus. The study of the initial level of TBC-active products and the increase in their concentration in the oral fluid of the research group, it showed that their value was significantly higher compared to the indicators of the representatives of the control group, which indicates an increase in lipid peroxidation. It was established that the catalase index and SOD activity of the salivary glands are significantly lower in the infected persons compared to similar indicators of the control group, which are due to long-term stress exposure, high emotional stress and depressive states of the patients and indicates the exhaustion of the antioxidant system. At the same time, there is an increase in such enzymes as glutathione peroxidase and glutathione reductase. It was found that the intensity of free radical processes and the imbalance of antioxidant systems increases with the deepening of immunodeficiency and with the progression of periodontal pathology. Key words: Sars-Cov-2 virus, generalized periodontitis , peroxidation, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase.

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Determination of the antimicrobial activity of a gel composition based on a flavonoid complex and benzidamine hydrochloride intended for the treatment of periodontal diseases in orthodontic patients

Hodovanyi,

Chukhray,

Kuzminov

et al. 2023

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Summary. It is important to solve the problem of complex treatment and prevention of periodontal diseases in orthodontic patients by developing new drugs that have antimicrobial, anti-inflammatory, antioxidant effects and are included in effective treatment regimens. Orthodontic treatment with fixed orthodontic appliances contributes to a significant decrease in the level of individual oral hygiene against the background of oxidative stress. Therefore, the aggressiveness of periodontal pathogenic microflora increases, which contributes to the deepening of the inflammatory process in the tissues of the periodontal complex. The aim of the study – to determine the antimicrobial activity of the developed periodontal gel composition based on flavonoid complex and benzidamine hydrochloride against microorganisms isolated from periodontal pockets of orthodontic patients with dystrophic-inflammatory diseases of periodontal tissues. Materials and Methods. The efficacy of antimicrobial preservatives of the patented gel composition “Benzidaflaziverdine” (GCB) and the comparison drug “Cholisal” was evaluated according to the recommendations given in the State Pharmacopoeia of Ukraine (SPU). GCB samples were inoculated with suspensions of daily cultures of reference strains of S. aureus, P. aeruginosa, C. albicans and Aspergillus so that the final concentration of colony forming units (CFU) was 105-106 per ml. Isolates obtained from the oral cavity and periodontal pockets of orthodontic patients (S. aureus, S. pyogenes, S. mutans, E. faecalis, Rothia sp, bacteria of the Actinomycetaceae family, P. aeruginosa, C. albicans) were also used. Samples were taken after 2, 7, 14 and 28 days and the concentration of CFU of microorganisms was determined. Two methods were used to determine the antimicrobial activity: the standard “well” method regulated by the SPU, as well as a modification of the suspension method for determining the specific activity of disinfectants and other antimicrobial substances and compounds. To assess the reduction in the concentration of microorganisms, the decimal logarithm of the reduction in CFU in the samples (Log10 rate of reduction) was calculated. Results and Discussion. The results of using a modification of the suspension method, the peculiarity of which was to dilute equal proportions of GCB with a bacterial suspension, showed a well-pronounced antibacterial activity of GCB. At the same time, the activity of GCB against methicillin-resistant S. aureus isolate did not differ from that against sensitive isolates. The activity of GCB can be characterized as species-specific; the effect on individual isolates of the same species differed slightly. GCB activity was high against streptococci, Rothia sp. and pseudomonas (P. aeruginosa). For S. aureus, S. pyogenes and C. albicans, the dynamics of the decrease in CFU during exposure to GCB for 40 minutes was determined. It was found that the maximum Lоg10 rate of reduction of CFU of staphylococcus aureus and pyogenic streptococcus occurred in the first 10-15 minutes of incubation. Thus, analyzing the results obtained, we found no statistically significant differences between the absolute values of Lоg10 CFU reduction for GCB and the comparison drug “Cholisal”. Conclusions. The developed GCB in terms of its antimicrobial properties fully meets the requirements of the SPU in terms of the indicator “antimicrobial activity of preservatives”. The probable synergism of a low dose of nipagine introduced into the composition and the antimicrobial properties of benzidamine hydrochloride, which is in optimal ratio with Proteflazid® (flavonoid complex), provided high antimicrobial properties of the developed drug, which can be recommended as a periodontal dressing for the treatment of periodontal tissue diseases in orthodontic patients in preparation for the active period of orthodontic treatment, and in cases of stopped remission at different periods of bracket systems use.

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The Main Risk Factors for Inflammatory Periodontal Disease in Young People

Cited by 4 publications

References 1 publication

Review the status of dental health and oral hygiene for young adult in Vietnam and in some countries

Review the status of dental health and oral hygiene for young adult in Vietnam and in some countries

The assessment of the status of the prooxidant-antioxidant system in patients with chronic generalized periodontitis in the post-сovid period

Determination of the antimicrobial activity of a gel composition based on a flavonoid complex and benzidamine hydrochloride intended for the treatment of periodontal diseases in orthodontic patients

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