The main phenolic compounds responsible for the antioxidant capacity of sweet cherry (Prunus avium L.) pulp

Clodoveo, Maria Lisa; Crupi, Pasquale; Muraglia, Marilena; Naeem, Muhammad; Tardugno, Roberta; Limongelli, Francesco; Corbo, Filomena

doi:10.1016/j.lwt.2023.115085

Cited by 12 publications

(5 citation statements)

References 37 publications

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“…Thus, five fractions exhibited a significant difference in antioxidant activities, and the Fr-EtOAc displayed the highest scavenging capacities of ABTS + and DPPH∙ free radicals and reducing ability of Fe 3+ , followed by Fr-nBuOH and Fr-CH 2 Cl 2 , which agreed with the results of TPC and TFC ( Figure 3 ). Similar findings had also been reported by Clodoveo et al ( 50 ) who evaluated the antioxidant activities of phenolic compounds in sweet cherry pulp. Meanwhile, the ABTS + and DPPH∙ free radicals scavenging capacities of five fractions were lower than vitamin C, but Fr-EtOAc and Fr-nBuOH exhibited excellent antioxidant activities with low IC 50 values of DPPH (0.23, 0.38 mg/mL) and ABTS (0.08, 0.16 mg/mL) assays.…”

Section: Resultssupporting

confidence: 90%

“…Furthermore, it was observed that FRAP depicted extremely significant ( p < 0.01) positive correlated with 16 individual compounds (except rutin), while DPPH was significantly ( p < 0.05) negative correlated with rutin. Similar results were also reported by Clodoveo et al ( 50 ) who evaluated the correlation between phenolic compounds from sweet cherry pulp and antioxidant activities (DPPH and ABTS assays). And the results of the present work demonstrated and confirmed the speculations of several recent researches on some unique phenolic compounds that contributed to higher antioxidant activities ( 59 , 60 ).…”

Section: Resultssupporting

confidence: 89%

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Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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Amomum villosum Lour. (A. villosum), known as Sharen in China, is widely used for culinary and medicinal purposes due to containing a diverse set of bioactive compounds. In this study, the optimum ethanol extraction process was optimized and the composition and biological activities (antioxidant and antitumor) of five different fractions (dichloromethane, petroleum ether, ethyl acetate, n-butanol and H2O) extracted from the ethanol extract of A. villosum were investigated. The results showed that the optimal extraction conditions were extraction temperature 80°C, extraction time 120 min, ethanol concentration 40% and solid–liquid ratio 1:25 g/mL. Moreover, 35 bioactive compounds were successfully identified by UPLC-ESI-QTOF-MS/MS from five factions for the first time, including 12 phenolic acids and derivatives, 2 organic acids, 12 flavonoids and derivatives, 2 oxylipins and 7 proanthocyanidins. Among them, ethyl acetate fraction (Fr-EtOAc) exhibited the highest content of total phenolic (374.01 mg GAE/g DW) and flavonoid (93.11 mg RE/g DW), where vanillic acid, catechin, epicatechin and protocatechuic acid were the predominant phenolic compounds that accounting for 81.65% of the quantified bioactive compounds. In addition, Fr-EtOAc demonstrated excellent total antioxidant activity (IC50 of DPPH and ABTS assays were 0.23, 0.08 mg/mL, respectively, and FRAP assay was 322.91 mg VCE/100 g DW) and antitumor activity (1,000 μg/mL, 79.04% inhibition rate). The results could provide guidance for the industrial production and application of A. villosum.

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 89%

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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“…As shown, the Cy-type was the major anthocyanins in bayberry wine, which includes five different compounds. The Cy-type is one of the most abundant classes of anthocyanins in nature, especially in red berries such as blueberries, bayberries, mulberries, sweet cherries, and black chokeberries ( Avula et al, 2023 , Clodoveo et al, 2023 ). In our study, most of the monoglycosidic anthocyanins are substituted at the C-3 position, which is the common substituted form of anthocyanins.…”

Section: Resultsmentioning

confidence: 99%

Metabolomic analysis to unravel the composition and dynamic variations of anthocyanins in bayberry-soaked wine during the maceration process

Li,

Chen,

Lyu

et al. 2024

Food Chemistry: X

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“…The redox properties of these compounds are exerted through both hydrogen atom transfer (HAT) and single electron transfer (SET) mechanisms of action [56]. Nevertheless, recent HPLC coupled to mass spectrometry and factorial analysis demonstrated synergistic free radical scavenging activity of the majority of tested polyphenols, such as quercetin-4 -glucoside, catechin, epicatechin, and caffeoyl and coumaroylquinic acid derivatives [57]. Still, the study showed that procyanidin B1 and chlorogenic acids presented only independent action.…”

Section: Free Radical Scavenging Capacitymentioning

confidence: 95%

The Chemical Profile, Antioxidant, and Anti-Lipid Droplet Activity of Fluid Extracts from Romanian Cultivars of Haskap Berries, Bitter Cherries, and Red Grape Pomace for the Management of Liver Steatosis

Craciunescu,

Seciu-Grama,

Mihai

et al. 2023

IJMS

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This study aimed to investigate, for the first time, the chemical composition and antioxidant activity of fluid extracts obtained from three Romanian cultivars of haskap berries (Lonicera caerulea L.) var. Loni, bitter cherries (Prunus avium var. sylvestris Ser.) var. Silva, and pomace from red grapes (Vitis vinifera L.) var. Mamaia, and their capacity to modulate in vitro steatosis, in view of developing novel anti-obesity products. Total phenolic, flavonoid, anthocyanin, and ascorbic acid content of fluid extracts was spectrophotometrically assessed and their free radical scavenging capacity was evaluated using Trolox Equivalent Antioxidant Capacity (TEAC) and free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical inhibition assays. The Pearson coefficients showed a moderate correlation between the antioxidant activity of fluid extracts and their phenolic content, but a strong correlation between anthocyanin and ascorbic acid content. HPLC analysis identified and quantified the main phenolic compounds of chlorogenic and syringic acid, catechin, and glycosylated kaempferol, apigenin, and quercetin, in variable proportions. An in vitro experimental model of steatosis was developed in HepG2 hepatocytes treated with a mixture of free fatty acids. Cell culture analyses showed that cytocompatible concentrations of fluid extracts could significantly reduce the lipid accumulation and inhibit the reactive oxygen species, malondialdehyde, and nitric oxide secretion in stressed hepatocytes. In conclusion, these results put an emphasis on the chemical compounds’ high antioxidant and liver protection capacity of unstudied fluid extracts obtained from Romanian cultivars of bitter cherries var. Silva and pomace of red grapes var. Mamaia, similar to the fluid extract of haskap berries var. Loni, in particular, the positive modulation of fat deposition next to oxidative stress and the lipid peroxidation process triggered by fatty acids in HepG2 hepatocytes. Consequently, this study indicated that these fluid extracts could be further exploited as hepatoprotective agents in liver steatosis, which provides a basis for the further development of novel extract mixtures with synergistic activity as anti-obesity products.

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The main phenolic compounds responsible for the antioxidant capacity of sweet cherry (Prunus avium L.) pulp

Cited by 12 publications

References 37 publications

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Metabolomic analysis to unravel the composition and dynamic variations of anthocyanins in bayberry-soaked wine during the maceration process

The Chemical Profile, Antioxidant, and Anti-Lipid Droplet Activity of Fluid Extracts from Romanian Cultivars of Haskap Berries, Bitter Cherries, and Red Grape Pomace for the Management of Liver Steatosis

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