The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats

Hudson, Alexandre Sérvulo Ribeiro; Soares, Anne Danieli Nascimento; Horta, Nayara Abreu Coelho; Fuscaldi, Leonardo Lima; Machado‐Moreira, Christiano A.; Soares, Danusa Dias; Coimbra, Cândido Celso; Poletini, Maristela O.; Cardoso, Valbert Nascimento; Wanner, Samuel Penna

doi:10.1016/j.jtherbio.2020.102610

Cited by 9 publications

(2 citation statements)

References 53 publications

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“…core body temperature ≥39.5°C) would result in Δ pre- to post-exercise ≥800 ng·mL −1 , which is in accordance with a recent EIGS biomarker reliability study proposing ≥780 ng·mL −1 for relevant minimal detectable change [ 4 ]. Such outcomes are in accordance with a recent murine experimental model, whereby Wister rats were subjected to 90 min treadmill exercise (15 m·min −1 ) in 13°C, 24°C, or 31°C ambient conditions, versus a 24°C rest control [ 51 ]. Compared with rest and exercising at the lower ambient temperatures, exercise in 31°C resulted in rats producing greater core temperature rises (e.g.…”

Section: Discussionsupporting

confidence: 84%

The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

et al. 2023

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Utilizing metadata from existing exertional and exertional-heat stress studies, the study aimed to determine if the exercise-associated increase in core body temperature can predict the change in exercise-induced gastrointestinal syndrome (EIGS) biomarkers and exercise-associated gastrointestinal symptoms (Ex-GIS). Endurance-trained individuals completed 2 h of running exercise in temperate (21.2-30.0°C) to hot (35.0-37.2°C) ambient conditions (n = 132 trials). Blood samples were collected pre- and post-exercise to determine the change in gastrointestinal integrity biomarkers and systemic inflammatory cytokines. Physiological and thermoregulatory strain variables were assessed every 10–15 min during exercise. The strength of the linear relationship between maximal (M-Tre) and change (Δ Tre) in rectal temperature and EIGS variables was determined via Spearman’s rank correlation coefficients. While the strength of prediction was determined via simple and multiple linear regression analyses dependent on screened EIGS and Ex-GIS confounding factors. Significant positive correlations between Tre maximum (M-Tre) and change (Δ Tre) with I-FABP (rs = 0.434, p < 0.001; and rs = 0.305, p < 0.001; respectively), sCD14 (rs = 0.358, p < 0.001; and rs = 0.362, p < 0.001), systemic inflammatory response profile (SIR-Profile) (p < 0.001), and total Ex-GIS (p < 0.05) were observed. M-Tre and Δ Tre significantly predicted (adjusted R2) magnitude of change in I-FABP (R2(2,123)=0.164, p < 0.001; and R2(2,119)=0.058, p = 0.011; respectively), sCD14 (R2(2,81)=0.249, p < 0.001; and R2(2,77)=0.214, p < 0.001), SIR-Profile (p < 0.001), and total Ex-GIS (p < 0.05). Strong to weak correlations were observed between M-Tre and Δ Tre with plasma concentrations of I-FABP, sCD14, SIR-Profile, and Ex-GIS in response to exercise. M-Tre and Δ Tre can predict the magnitude of these EIGS variables and Ex-GIS in response to exercise.

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Section: Discussionsupporting

confidence: 84%

The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

et al. 2023

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“…Exercise in higher ambient temperatures significantly increases levels of I-FABP in humans [ 74 ]. Similarly, rats that exercise in warmer environments (31°C) exhibit increased intestinal permeability to radiolabeled 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) compared to cooler environments (13°C–24°C) and display heightened mRNA levels of tight junction related genes in what is hypothesized to be an attenuated attempt to palliate the increased intestinal permeability, but the proteins’ expressions were not directly measured in this study [ 75 ]. Such findings highlight the individual physiological status determining heat stress response.…”

Section: Heat Stroke and Autodigestion: Comprehensive Review Of Articles Linking Heat Stress And Autodigestionmentioning

confidence: 99%

Enhanced intestinal permeability and intestinal co-morbidities in heat strain: A review and case for autodigestion

et al. 2021

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Enhanced intestinal permeability is a pervasive issue in modern medicine, with implications demonstrably associated with significant health consequences such as sepsis, multiorgan failure, and death. Key issues involve the trigger mechanisms that could compromise intestinal integrity and increase local permeability allowing the passage of larger, potentially dangerous molecules. Heat stress, whether exertional or environmental, may modulate intestinal permeability and begs interesting questions in the context of global climate change, increasing population vulnerabilities, and public health. Emerging evidence indicates that intestinal leakage of digestive enzymes and associated cell dysfunctions--a process referred to as autodigestion--may play a critical role in systemic physiological damage within the body. This increased permeability is exacerbated in the presence of elevated core temperatures. We employed Latent Dirichlet Allocation (LDA) topic modeling methods to analyze the relationship between heat stress and the nascent theory of autodigestion in a systematic, quantifiable, and unbiased manner. From a corpus of 11,233 scientific articles across four relevant scientific journals (Gut, Shock, Temperature, Gastroenterology), it was found that over 1,000 documents expressed a relationship between intestine, enhanced permeability, core temperature, and heat stress. The association has grown stronger in recent years, as heat stress and potential autodigestion are investigated in tandem, yet still by a limited number of specific research studies. Such findings justify the design of future studies to critically test novel interventions against digestive enzymes permeating the intestinal tract, especially the small intestine.

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Determinants of body core temperatures at fatigue in rats subjected to incremental-speed exercise: The prominent roles of ambient temperature, distance traveled, initial core temperature, and measurement site

et al. 2023

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The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats

Cited by 9 publications

References 53 publications

The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

Enhanced intestinal permeability and intestinal co-morbidities in heat strain: A review and case for autodigestion

Determinants of body core temperatures at fatigue in rats subjected to incremental-speed exercise: The prominent roles of ambient temperature, distance traveled, initial core temperature, and measurement site

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