The Magnitude of Hemoconcentration with Eclampsia

Abstract

Women with eclampsia have significantly decreased blood volumes at term compared with normally pregnant women. In subsequent normotensive pregnancies, blood volume expansion in these women is normal.

Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies

“…The circulating blood volume is markedly reduced in women with preeclampsia and eclampsia [16,19], and this phenomenon may be explained partly by insufficient aldosterone production [5] based on the following findings: 1) serum and urinary aldosterone is suppressed in women with preeclampsia [2][3][4]10], as was also shown in this study; 2) urinary aldosterone (tetrahydro-aldosterone) is inversely correlated with blood pressure during pregnancy [4]; and 3) supplemental NaCl administration during pregnancy was useful for reducing the blood pressure to within a normal range in a woman with a genetic predisposition to insufficient aldosterone production [6], suggesting that a sufficient and adequate blood volume determined primarily by the PAC prevents the development of preeclampsia. Thus, the suppression of PAC, compared with that in normotensive women, is a characteristic feature of women who develop preeclampsia and may be responsible for the development of preeclampsia.…”

Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

“…However, the circulating blood volume is markedly reduced in women with preeclampsia [10] and is lowest among women progressing to eclampsia [19]. Although the precise mechanisms leading to the contraction of the circulating plasma volume are not well understood, an increased blood vessel permeability in response to vascular endothelial cell dysfunction allowing the leakage of the plasma into the extravascular space may be one of the possible explanations [20].…”

“…Although difference did not reach a significant level mainly due to a small number of study subjects with hypertension in this study, a reduced AT activity is one of the laboratory characteristics seen in women with preeclampsia, eclampsia, and HELLP syndrome [1][2][3][4]19]. Six out of 11 women with eclampsia exhibited a reduced AT activity of less than 65% of the normal activity level before or soon after an eclamptic fit [21].…”

The prevention and management of postpartum hemorrhage

“…Gebelikte kan hacmi yüzde 30-60 artış gösterir, yani normal vücut yapısındaki bir gebe için yaklaşık 1500-2000 ml hacim artışı söz konusudur (14) . Gebelikte yeterli kan hacmi artışı olmayan kronik renal yetmezlikli, preeklamptik ve eklamptik, küçük vücut yapılı olgular ile anemik ve dehidrate olgular kan kaybı ile hemodinamik bozulmaya yatkın olmaları nedeni ile postpartum kanamanın neden olduğu morbidite ve mortalite açısından yüksek risklilerdir (15) .…”