The Magnitude and Duration of Respiratory Depression Produced by Fentanyl and Fentanyl Plus Droperidol in Man

Harler, M. H.; Hickey, Rosemary; Cromwell, Thomas H.; Linwood, S.

doi:10.1097/00132586-197708000-00005

Cited by 19 publications

(29 citation statements)

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“…Neither did we find any enhancement by haloperidol in nalbuphine induced respiratory depression. Droperidol together with the ,u-agonist fentanyl (Harper et al, 1976) or methotrimeprazine combined with morphine (Petts et al, 1983) did not increase or prolong the respiratory depression seen with the opioids alone. In contrast, chlorpromazine produced stronger and longer respiratory depression than plain meperidine, and similar effects have been found with prochlorperazine and morphine, and propiomazine and meperidine (Keats, 1985).…”

Section: Side Effectsmentioning

confidence: 80%

Psychomotor, respiratory and neuroendocrinological effects of nalbuphine and haloperidol, alone and in combination, in healthy subjects.

Saarialho–Kere

1988

Brit J Clinical Pharma

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1 Actions and interactions on performance and respiration of single intramuscular doses of 0.15 mg kg-' nalbuphine and oral haloperidol twice daily for 2 days were studied double-blind and cross-over in 12 healthy volunteers. 2 Objective measurements of performance (choice reaction, tracking, attention, flicker fusion, Maddox wing, digit symbol substitution) and respiratory function (minute volume, end-tidal carbon dioxide), and subjective assessments on visual analogue scales were done at baseline and 1 h, 2.5 h and 4 h after the injection of nalbuphine. Plasma concentrations of nalbuphine were estimated by radioreceptor ([3H]-dihydromorphine) assay, and those of prolactin and growth hormone by radioimmunoassay. 3 Nalbuphine affected digit substitution, reaction time, extraocular muscle balance and flicker recognition, and depressed respiration most clearly 1 and 2.5 h post injection. Motor skills were impaired only briefly. Haloperidol alone proved inert on performance but enhanced the decremental effects of nalbuphine on digit substitution and exophoria at 1 h. It did not interact with nalbuphine on the ventilatory function. 4 Plasma concentrations of nalbuphine expressed as morphine equivalents ranged from 5 to 52 ng ml-', indicating considerable ,u-opiate affinity. Treatment with haloperidol increased plasma prolactin moderately whilst nalbuphine raised it markedly 1 and 2.5 h post injection. Nalbuphine elevated plasma growth hormone at 1 h post injection only.

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Section: Side Effectsmentioning

confidence: 80%

Psychomotor, respiratory and neuroendocrinological effects of nalbuphine and haloperidol, alone and in combination, in healthy subjects.

Saarialho–Kere

1988

Brit J Clinical Pharma

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“…One of the major side effects of opioids is respiratory depression. Opioids, even administered at low doses may suppress the minute ventilation and increase PaCO2 for 2 to 4 hours [14]. Respiratory depression and even apnea is the most common complication following I.V.…”

Section: Discussionmentioning

confidence: 99%

Physiological Effects of Balanced Anesthesia during Dental Procedures in Brown Bears (Ursus Arctos)

et al. 2017

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The goal of the present study was to monitor the physiological effects of a standardized balanced anesthetic protocol in brown bears (Ursus arctos) during routine dental procedures. Physiological parameters (rectal temperature, heart rate, respiratory rate and oxygen saturation) were evaluated in twelve brown bears, anesthetized with a balanced drug combination for 90 minutes during dental procedures. The animals were kept in the "Park for Dancing Bears" Belitza, Bulgaria. A standardized premedication protocol of a combined intramuscular injection of tiletamine HCl and zolazepam HCl (Zoletil 100® Virbac, France) 1mg/kg, medetomidine HCl 0.003mg/kg and 0.05 mg/kg of butorphanol was administered intramuscularly. Anesthesia was induced intravenously with a combined bolus of ketamine at 2 mg/kg and propofol at 2 mg/kg, and maintained with a constant rate infusion (CRI) of ketamine at 0.8 mg/kg/h and propofol 0.04 at mg/kg/min. Rectal temperature decreased signifi cantly during anesthesia, whereas: heart rate, respiratory rate and oxygen saturation were stable with no signifi cant changes in these parameters for the duration of anesthesia. In conclusion, this anesthetic drug combination is suitable for oral surgery of medium duration in brown bears.

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“…After the high dose of fentanyl, and in association with elevation of PEa'CO2, depression in the slope was expected. 16 Most studies utilizing the ventilatory response to CO2 have not been on awake, intubated, postoperafive patients, and none have been conducted postcardiac surgery. This method of assessing respiratory depression is more sensitive than resting CO2 levels, t7 Degree of arousal affects the slope of the response, t7 and our patients certainly experienced varying levels of comfort, aletmess, and stimulation throughout the postoperative period.…”

Section: Discussionmentioning

confidence: 99%

Early extubation after high-dose fentanyl anaesthesia for aortocoronary bypass surgery: reversal of respiratory depression with low-dose nalbuphine

et al. 1985

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The Magnitude and Duration of Respiratory Depression Produced by Fentanyl and Fentanyl Plus Droperidol in Man

Cited by 19 publications

References 0 publications

Psychomotor, respiratory and neuroendocrinological effects of nalbuphine and haloperidol, alone and in combination, in healthy subjects.

Psychomotor, respiratory and neuroendocrinological effects of nalbuphine and haloperidol, alone and in combination, in healthy subjects.

Physiological Effects of Balanced Anesthesia during Dental Procedures in Brown Bears (Ursus Arctos)

Early extubation after high-dose fentanyl anaesthesia for aortocoronary bypass surgery: reversal of respiratory depression with low-dose nalbuphine

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