The Magnitude and associated factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji Hospital, Southeast Ethiopia

Abstract

Background: Helicobacter pylori infection is the most common chronic bacterial infection and there were approximately 4.4 billion individuals with H pylori infection worldwide. Among those, hundreds of millions of people develop peptic ulcer disease during their lifetime and still tens of millions might progress to gastric cancer. Hence, early information is very important to prevent upper gastrointestinal complications. Consequently, the current study aimed to assess the magnitude and associated risk factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji hospital, Southeast Ethiopia.Methods: A hospital-based cross-sectional study involving 348 adult dyspeptic patients attending Bokoji hospital was carried out from July 16 to October 31, 2019. About 50 mg of fresh stool and 60 µl of capillary blood were collected from each dyspeptic patient and analyzed for detection of Helicobacter pylori antigens, presence of intestinal parasites and ABO blood grouping respectively. Data were entered using Epi Info 7 and Statistical analysis was done using SPSS version 21 and a p-value less than 0.05 was considered as statistically significant.Results: The overall magnitude of Helicobacter pylori infection was 47.7%. The magnitude of H. pylori infection was almost two times higher in patients who do not have a habit of handwashing after toilet visit than those who wash their hand's habit of handwashing after visiting toilet (AOR 2.241, 95% CI (1.410, 3.563) and alcohol drinking habit (AOR 1.796, 95% CI (1.087, 2.968). Conclusions: The magnitude of H. pylori was high in the study area and associated with handwashing habits after toilet use and alcohol drinking habits. Therefore, the community could be educated on the handwashing habit to minimize H. pylori infections.

Sero- and Feco-Prevalence of Helicobacter pylori Infection and Its Associated Risk Factors among Adult Dyspeptic Patients Visiting the Outpatient Department of Adet Primary Hospital, Yilmana Densa District, Northwest Ethiopia

“…Te result of this study also showed that the odds of H. pylori infection were about 12.34 times higher among dyspeptic patients who consumed alcohol than those who did not consume alcohol. Tis fnding is in agreement with studies conducted in Uganda (21), Bekoji (southeast of Ethiopia) [13], Cameron [61], Shashamane (Ethiopia) [14], Dessie (Ethiopia) [16], Indonesia [62], and Hosaena (Ethiopia) [47]. It is highly likely that alcohol can directly damage the gastric mucosal layer, favouring the attachment of the bacterium to the wall of the stomach.…”

“…Te overall feco-prevalence of H. pylori infection in this study was 51.1%. It is in line with fndings from Hosaena town of southeast Ethiopia (51.4%) [47], Uganda (47.7%) [48], Bekoji (southeast Ethiopia) (47.7%) [13], Egypt (53.1%) [49], Iraq (54%) [50], and Nigeria (55%) [51]. It was lower Canadian Journal of Infectious Diseases and Medical Microbiology than studies conducted in Sudan (70%) [26], Sekota (northeast Ethiopia) (64.8%) [52], and Pakistan (66.66%) [53].…”

“…In a meta-analysis study, the overall pooled prevalence of H. pylori infection was found to be 52.2%, with the Somali region having the highest prevalence (71%), followed by the Amhara region with a prevalence of 54.6% [10]. Te prevalence of H. pylori varied across geographical locations in Ethiopia; it was 42.8% in Mizan Aman town, Southwest Ethiopia [11], 72% among gastritis patients attending Yekatit 12 Teaching Hospital of Addis Ababa [12], 47.7% in Bekoji [13], 30.3% in Shashamane, Ethiopia [14], and 65.7% in Ziway, central Ethiopia (65.7%) [15]. Te frequency of H. pylori infection is also very high in the Amhara Regional State, but it is varied in diferent locations in the region.…”

Helicobacter pylori infection and related factors among pregnant women at Debre Tabor General Hospital, Northwest Ethiopia, 2021: Anemia highly related with H. pylori

“…Handwashing practice was found to be another significant factor associated with the prevalence of H. pylori infection and participants who had practiced handwashing sometimes with AOR (95% CI: 3.090 [1.144–8.348) were 3.1 times more likely to have the H. pylori infection compared with those who had practiced handwashing immediately after contact with dirt, which is consistent with other studies done in Ethiopia, 10 , 47 University of Maiduguri Teaching Hospital Borno State Nigeria, 22 and Alaska Area Indian; 17 this suggests that the mode of transmission of H. pylori could be the result from the fecal–oral route that can relate to poor hygienic practices (handwashing). Ingestion is not the only means of transmission potentially affected by water.…”

Helicobacter pylori infection and related factors among pregnant women at Debre Tabor General Hospital, Northwest Ethiopia, 2021

“…Hand washing practice found to be another signi cant factor associated with the prevalence of Helicobacter pylori infection and participants who had practiced hand washing sometimes with AOR [95% CI: 3.090 [1.144-8.348] were 3.1 times more likely to have the Helicobacter pylori infection as compared to who had practiced hands washing immediately after contact with dirt which is consistent with other studies done in Ethiopia (10,50), University of Maiduguri Teaching Hospital Borno State Nigeria (22), Alaska Area Indian (17); this suggest that mode of transmission of H. pylori could be the result from the fecal-oral route that can relate to poor hygienic practices (handwashing). Ingestion is not the only means of transmission potentially affected by water.…”