The magnetization transfer characteristics of human breast tissues: an<i>in vitro</i>NMR study

Callicott, C; Thomas, Jason M.; Goode, A W

doi:10.1088/0031-9155/44/5/003

Cited by 17 publications

(16 citation statements)

References 19 publications

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“…As expected from previous studies, the 2-back verbal working memory task engaged a bilateral network comprising frontal, parietal and cingulate cortex (Callicott et al 1999). Consistent with our hypothesis, ATD, within this network, altered activation in the dorsolateral and medial Coordinates refer to the voxel with the maximum SSQ ratio in each cluster in stereotactic space as defined in the atlas of Talairach and Tournoux (1998) PFC.…”

Section: Discussionsupporting

confidence: 89%

Effect of acute tryptophan depletion on pre-frontal engagement

Allen¹,

Cleare²,

Lee³

et al. 2006

Psychopharmacology

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Section: Discussionsupporting

confidence: 89%

Effect of acute tryptophan depletion on pre-frontal engagement

Allen¹,

Cleare²,

Lee³

et al. 2006

Psychopharmacology

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“…Schreiber et al (37) noted improved visualization of tissue enhancement in MT-weighted images after the injection of a standard gadolinium-based contrast agent. Callicott et al (38) assessed T 1 and MT properties on breast tissue samples ex vivo. Although these MT methods were able to provide greater discrimination between lesions and the surrounding normal tissue, they were unable to reliably separate benign from malignant neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

et al. 2016

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Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique’s reproducibility in healthy breast tissue must be established. Thus, this study aims to establish the reproducibility of the measurement of the macromolecular-to-free water proton pool size ratio (PSR) in healthy fibroglandular (FG) breast tissue. Thirteen women with no history of breast disease were scanned twice within a single scanning session, with repositioning between scans. Eleven women had appreciable FG tissue for test–retest measurements. Mean PSR values for the FG tissue ranged from 9.5% to 16.7%. The absolute value of the difference between 2 mean PSR measurements for each volunteer ranged from 0.1% to 2.1%. The 95% confidence interval for the mean difference was ±0.75%, and the repeatability value was 2.39%. These results indicate that the expected measurement variability would be ±0.75% for a cohort of a similar size and would be ±2.39% for an individual, suggesting that future studies of change in PSR in patients with breast cancer are feasible.

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“…In an in vitro nuclear magnetic resonance study, Callicott et al (2) found that the cross-relaxation rate is a more sensitive parameter than the saturation transfer ratio for characterizing human breast tissue. The cross-relaxation rate is defined as the magnetization transfer rate constant.…”

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confidence: 99%

Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience

et al. 2010

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ObjectiveEquivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML).Materials and MethodsInstitutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm.ResultsThe median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 ± 0.17 × 106 / mm2 in FL and 1.0 ± 0.70 × 106 / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%.ConclusionA strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.

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The magnetization transfer characteristics of human breast tissues: anin vitroNMR study

Cited by 17 publications

References 19 publications

Effect of acute tryptophan depletion on pre-frontal engagement

Effect of acute tryptophan depletion on pre-frontal engagement

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience

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