The MADS-domain protein PPM2 preferentially occurs in gametangia and sporophytes of the moss Physcomitrella patens

Quodt, Vanessa; Faigl, Wolfram; Saedler, Heinz; Münster, Thomas

doi:10.1016/j.gene.2007.05.016

Cited by 16 publications

(21 citation statements)

References 32 publications

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“…Comparative studies between P. patens and Arabidopsis have indicated that the consecutive evolution of this new structure involved the modification of sporophytespecific developmental programs (Maizel et al 2005;Tanahashi et al 2005), as well as a recruitment of gametophytic developmental programs into the sporophytic generation (Nishiyama et al 2003;Menand et al 2007). MIKC c MADS-box genes seem to have largely undergone the latter fate because they are expressed in both the gametophyte and the sporophyte in mosses and ferns (Munster et al 1997;Hasebe et al 1998;Quodt et al 2007) and almost exclusively in the sporophyte in Arabidopsis (Kofuji et al 2003). On the other hand, our data suggest that MIKC* MADS-box genes have generally retained a role in the gametophytic generation of land plants.…”

Section: Evolutionary Diversification Of the Mikc* Mads-box Gene Cladementioning

confidence: 69%

MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

Zobell

Faigl

Saedler

et al. 2010

Molecular Biology and Evolution

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Land plants (embryophytes) are characterized by an alternation of two generations, the haploid gametophyte and the diploid sporophyte. The development of the small and simple male gametophyte of the flowering plant Arabidopsis (Arabidopsis thaliana) critically depends on the action of five MIKC* group MCM1-AGAMOUS-DEFICIENS-SRF-box (MADSbox) proteins. In this study, these MIKC* MADS-box genes were isolated from land plants with relatively large and complex gametophyte bodies, namely the bryophytes. We found that although the gene family expanded in the mosses Sphagnum subsecundum, Physcomitrella patens, and Funaria hygrometrica, only a single homologue, Marchantia polymorpha MADSbox gene 1 (MpMADS1), has been retained in the liverwort M. polymorpha. Liverworts are the earliest diverging land plants, and so a comparison of MpMADS1 with its angiosperm homologues addresses the molecular evolution of an embryophyte-specific transcription factor over the widest phylogenetic distance. MpMADS1 was found to form a homodimeric DNA-binding complex, which is in contrast to the Arabidopsis proteins that are functional only as heterodimeric complexes. The M. polymorpha homodimer, nevertheless, recognizes the same DNA sequences as its angiosperm counterparts and can functionally replace endogenous MIKC* complexes to a significant extent when heterologously expressed in Arabidopsis pollen. The 11 MIKC* homologues from the moss F. hygrometrica are highly and almost exclusively expressed in the gametophytic generation. Taken together, these findings suggest that MIKC* MADSbox proteins have largely preserved molecular roles in the gametophytic generation of land plants.

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Section: Evolutionary Diversification Of the Mikc* Mads-box Gene Cladementioning

confidence: 69%

MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

Zobell

Faigl

Saedler

et al. 2010

Molecular Biology and Evolution

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“…Given the ubiquitous presence of MADS-box genes in embryophytes together with what we know already about their important roles in the development and evolution of spermatophytes, it is clear that we should now afford a high priority to functional analyses of the complete MADS-box gene complement discerned within the S. moellendorffii genome. It will be interesting to discover, for example, whether any of the S. moellendorffii genes encode a reproductive function as has been shown for some MIKC C genes in P. patens (Quodt et al, 2007; Singer et al, 2007) and appears likely for charophycean algae (Tanabe et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

Selaginella Genome Analysis – Entering the “Homoplasy Heaven” of the MADS World

Gramzow¹,

Barker²,

Schulz³

et al. 2012

Front. Plant Sci.

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In flowering plants, arguably the most significant transcription factors regulating development are MADS-domain proteins, encoded by Type I and Type II MADS-box genes. Type II genes are divided into the MIKCC and MIKC* groups. In angiosperms, these types and groups play distinct roles in the development of female gametophytes, embryos, and seeds (Type I); vegetative and floral tissues in sporophytes (MIKCC); and male gametophytes (MIKC*), but their functions in other plants are largely unknown. The complete set of MADS-box genes has been described for several angiosperms and a moss, Physcomitrella patens. Our examination of the complete genome sequence of a lycophyte, Selaginella moellendorffii, revealed 19 putative MADS-box genes (13 Type I, 3 MIKCC, and 3 MIKC*). Our results suggest that the most recent common ancestor of vascular plants possessed at least two Type I and two Type II genes. None of the S. moellendorffii MIKCC genes were identified as orthologs of any floral organ identity genes. This strongly corroborates the view that the clades of floral organ identity genes originated in a common ancestor of seed plants after the lineage that led to lycophytes had branched off, and that expansion of MIKCC genes in the lineage leading to seed plants facilitated the evolution of their unique reproductive organs. The number of MIKC* genes and the ratio of MIKC* to MIKCC genes is lower in S. moellendorffii and angiosperms than in P. patens, correlated with reduction of the gametophyte in vascular plants. Our data indicate that Type I genes duplicated and diversified independently within lycophytes and seed plants. Our observations on MADS-box gene evolution echo morphological evolution since the two lineages of vascular plants appear to have arrived independently at similar body plans. Our annotation of MADS-box genes in S. moellendorffii provides the basis for functional studies to reveal the roles of this crucial gene family in basal vascular plants.

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“…Therefore, BELL1 might play a role in male fertility in P. patens. MADSbox genes are important for flower, pollen and fruit development (Theißen et al 2016) and have previously been associated with sexual reproduction in P. patens (Hohe et al 2002, Quodt et al 2007, Singer et al 2007. P. patens MIKC c -type genes are important for motile flagella and external water conduction (Koshimizu et al 2018).…”

Section: Rna-seq Of Male Reproductive Organs Suggests Differential Trmentioning

confidence: 99%

Characterization of evolutionarily conserved key players affecting eukaryotic flagellar motility and fertility using a moss model

Meyberg

Perroud

Haas

et al. 2019

Preprint

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Defects in flagella/cilia are often associated with infertility and disease. Motile male gametes (sperm cells) with flagella are an ancestral eukaryotic trait that has been lost in several lineages, for example in flowering plants. Here, we made use of a phenotypic male fertility difference between two moss (Physcomitrella patens) strains to explore spermatozoid function. We compare genetic and epigenetic variation as well as expression profiles between the Gransden and Reute strain to identify a set of genes associated with moss male infertility. Defects in mammal and algal homologs of these genes coincide with a loss of fertility, demonstrating the evolutionary conservation of flagellar function related to male fertility across kingdoms. As a proof of principle, we generated a loss-of-function mutant of a coiled-coil domain containing 39 (ccdc39) gene that is part of the flagellar hydin network. Indeed, the Ppccdc39 mutant resembles the male infertile Gransden strain phenotype. Potentially, several somatic (epi-)mutations occurred during prolonged vegetative propagation of P. patens Gransden, causing regulatory differences of e.g. the homeodomain transcription factor BELL1. Probably these somatic changes are causative for the observed male fertility. We propose that P. patens spermatozoids might be employed as an easily accessible system to study male infertility of human and animals.

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The MADS-domain protein PPM2 preferentially occurs in gametangia and sporophytes of the moss Physcomitrella patens

Cited by 16 publications

References 32 publications

MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

MIKC* MADS-Box Proteins: Conserved Regulators of the Gametophytic Generation of Land Plants

Selaginella Genome Analysis – Entering the “Homoplasy Heaven” of the MADS World

Characterization of evolutionarily conserved key players affecting eukaryotic flagellar motility and fertility using a moss model

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