The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

Silverstein, Emanuel; Freedman, Sharon F.; Zéhil, Gérard-Philippe; Jiramongkolchai, Kim; El-Dairi, Mays

doi:10.1016/j.jaapos.2016.05.013

Cited by 19 publications

(13 citation statements)

References 27 publications

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“…We have not observed cysts or changes in the outer and inner retinal layers except the absence of the ELM in all patients with PCG. Thickening of the INL in our study confirmed the results of Silverstein et al 21. However, missing ELM have not been described previously and could be caused by pathological retinal development and/or photoreceptor damage due to the raised IOP in PCG.…”

Section: Discussionsupporting

confidence: 91%

Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography

et al. 2019

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ObjectiveTo investigate (1) the feasibility of scanning the optic nerve (ON) and central retina with hand-held optical coherence tomography (HH-OCT) without sedation or anaesthesia in primary congenital glaucoma (PCG), (2) the characteristics of ON changes in comparison with adult primary open-angle glaucoma (POAG) in comparison with matched controls, (3) the sensitivity and specificity of ON parameters for diagnosis, and (4) changes of foveal morphology.Methods and analysisHH-OCT (Envisu 2300; Leica Microsystems) was used to investigate ON and foveal morphology of 20 children with PCG (mean age 4.64±2.79) and 10 adult patients with POAG (mean age 66.8±6.94), and compared with age-matched, gender-matched and ethnicity-matched healthy controls without sedation or anaesthesia.ResultsHH-OCT yielded useful data in 20 out of 24 young children with PCG. Patients with PCG had significantly deeper cup changes than patients with POAG (vs respective age-matched controls, p=0.014). ON changes in PCG are characterised by significant increase in cup depth (165%), increased cup diameter (159%) and reduction in rim area (36.4%) as compared with controls with high sensitivity (81.5, 74.1% and 88.9%, respectively) and specificity (85.0, 80.0% and 75.0%, respectively). Patients with PCG have a significantly smaller width of the macula pit (p<0.001) with non-detectable external limiting membrane.ConclusionHH-OCT has the potential to be a useful tool in glaucoma management for young children. We have demonstrated the use of HH-OCT in confirming a diagnosis of glaucoma within the studied cohort and found changes in disc morphology which characterise differently in PCG from POAG.

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Section: Discussionsupporting

confidence: 91%

Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography

et al. 2019

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“…[56][57][58] The evaluation of glaucomatous damage in monitoring childhood glaucoma can be challenging in the future, 59,60 even though children with glaucoma demonstrated decreased RNFL thickness and inner retina macular layers. 61,62 The GCL-IPL values were found to be thicker in the pediatric population with respect to adults, confirming the necessity of using a pediatric reference database to avoid false estimation with the adult normative database. 63,64 The Utility of Ganglion Cell…”

Section: Diagnostic Accuracy Reproducibility and Clinical Validationmentioning

confidence: 83%

<p>Ganglion Cell Complex Analysis in Glaucoma Patients: What Can It Tell Us?</p>

Scuderi¹,

Fragiotta²,

Scuderi³

et al. 2020

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Glaucoma is a group of optic neuropathies characterized by a progressive degeneration of retina ganglion cells (RGCs) and their axons that precedes functional changes detected on the visual field. The macular ganglion cell complex (GCC), available in commercial Fourier-domain optical coherence tomography, allows the quantification of the innermost retinal layers that are potentially involved in the glaucomatous damage, including the retinal nerve fiber (RNFL), ganglion cell and inner plexiform layers. The average GCC thickness and its related parameters represent a reliable biomarker in detecting preperimetric glaucomatous damage. The most accurate GCC parameters are represented by average and inferior GCC thicknesses, and they can be associated with progressive visual field loss. Although the diagnostic accuracy increases with more severe glaucomatous damage and higher signal strength values, it is not affected by increasing axial length, resulting in a more accurate discrimination of glaucomatous damage in myopic eyes with respect to the traditional RNFL thickness. The analysis of the structure-function relationship revealed a good agreement between the loss in retinal sensitivity and GCC thickness. The use of a 10-2°v isual field grid, adjusted for the anatomical RGCs displacement, describes more accurately the relationship between RGCs thickness and visual field sensitivity loss.

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“…These observations are consistent with those of other studies. For instance, Ghasia et al [10] showed a decreased of cpRNFL thickness in pediatric glaucomatous eyes compared with healthy eyes and Silverstein et al [12] reported significant statistical differences in volumes of each macular layers between healthy and glaucoma children using Spectralis OCT. We included foveal thickness corresponding to the 1 mmdiameter central zone. As expected, no differences in this variable was detected between the normal and glaucomatous eyes in any of the three layers examined.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma

Morales-Fernández

Jiménez-Santos

Martinez-de-la-Casa

et al. 2018

Eye

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The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

Cited by 19 publications

References 27 publications

Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography

Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography

<p>Ganglion Cell Complex Analysis in Glaucoma Patients: What Can It Tell Us?</p>

Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma

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