The macrosomic fetus: a challenge in current obstetrics

Henriksen, Tore

doi:10.1080/00016340801899289

Cited by 379 publications

(345 citation statements)

References 176 publications

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“…The LGA rate did not differ significantly among the subgroups of patients having FET after different endometrial preparation: there were 17 LGA neonates born after FET in spontaneous cycle (18 %), 10 LGA neonates born after FET using minimal stimulation (12 %), and 2 LGA neonates born after hormonal replacement therapy (25 %) (p=0.386).…”

Section: Resultsmentioning

confidence: 93%

“…The LGA child has an increased risk for stillbirth, asphyxia, distress, trauma, caesarian section, and metabolic disturbances at birth [15][16][17]. Moreover, another concern in LGA neonates born after assisted reproductive techniques (ART) is the possible underlying epigenetic pathology, since certain rare Capsule Besides maternal BMI, FET is a significant independent LGA risk factor in IVF patients.…”

Section: Introductionmentioning

confidence: 99%

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Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

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Purpose Higher risk for birth of singletons being large for gestational age (LGA) has been revealed after in vitro fertilization (IVF) frozen-thawed embryo-transfer (FET). This phenomenon is now being investigated, since there is a speculation that these neonates could suffer from underlying epigenetic disturbances. The aim of the study was to expose independent LGA risk factors and to identify those connected to the IVF techniques. Methods Altogether, 4508 singleton pregnancies and births were included in the cohort case-matched study. Two hundred eleven singleton pregnancies and births after FET and 916 after fresh embryo transfer (ET) were included into two study groups. The IVF procedures were performed at the University Medical Centre Ljubljana between 2004 and 2011. For each IVF pregnancy, three matched consecutive controls after natural conception were included. Using logistic regression models, we observed LGA connection to maternal parameters (smoking, hypertension, parity, BMI, gestational diabetes, IVF conception, FET, double ET, and ICSI procedure).Results Singletons born after FET had a significantly higher risk for being LGA (p=0.032; OR 1.697; 95 % CI 1.047-2.752). BMI 25-30 was a significant independent risk factor for LGA in the IVF groups (FET p=0.041, OR 2.460, 95 % CI 1.030-5.857 and fresh ET p=0.003; OR 2.188, 95 % CI 1.297-3.691). ICSI and double ET had no significant effect on LGA occurrence. Conclusions Besides maternal BMI, FET is a significant independent LGA risk factor in IVF patients. Other observed factors (smoking, hypertension, multiparity, GDM, ICSI procedure, or number of embryos transferred) do not influence LGA risk significantly.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

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“…However, it is just this delineation of the normal weight collective from the abnormally under-or overweight fetuses that is of decisive importance for the prenatal and obstetric management. Interuterine growth retardation as well as macrosomia carry significant risks for not only neonatal but also for maternal morbidity and mortality [9][10][11]. A differentiation from the normal collective can only be made when at least the weight estimation can reliably be classified in this range.…”

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confidence: 99%

Comparison of Errors of 35 Weight Estimation Formulae in a Standard Collective

Hoopmann

Kagan

Sauter

et al. 2016

Geburtshilfe Frauenheilkd

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The estimation of foetal weight is an integral part of prenatal care and obstetric routine. In spite of its known susceptibility to errors in cases of underweight or overweight babies, important obstetric decisions depend on it. In the present contribution we have examined the accuracy and error distribution of 35 weight estimation formulae within the normal weight range of 2500-4000 g. The aim of the study was to identify the weight estimation formulae with the best possible correspondence to the requirements of clinical routine. Materials and Methods: 35 clinically established weight estimation formulae were analysed in 3416 foetuses with weights between 2500 and 4000 g. For this we determined and compared the mean percentage error (MPE), the mean absolute percentage error (MAPE), and the proportions of estimates within the error ranges of 5, 10, 20 and 30%. In addition, separate regression lines were calculated for the relationship between estimated and actual birth weights for the weight range 2500-4000 g. The formulae were thus examined for possible inhomogeneities. Results: The lowest MPE were achieved with the Hadlock III and V formulae (0.8%, STW 9.2 % or, respectively, −0.8 %, STW 10.0 %). The lowest absolute error (6.6 %) as well as the most favourable frequency distribution in cases below 5 % and 10 % error (43.9 and 77.5) were seen for the Halaska formula. In graphic representations of the regression lines, 16 formulae revealed a weight overestimation in the lower weight range and an underestimation in the upper range. 14 formulae gave underestimations and merely 5 gave overestimations over the entire tested weight range. Conclusion: The majority of the tested formulae gave underestimations of the actual birth weight over the entire weight range or at least in the upper weight range. This result supports the cur-

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“…(Скандинавский комитет по ВРТ и безопасности -CoNARTaSgroup), представлено от-дельным анализом исходов по криоциклам (n=6647 [21].…”

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