2022
DOI: 10.1016/j.jid.2022.06.013
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The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation

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Cited by 4 publications
(3 citation statements)
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“…M3 mAChR knockout mice ( Chmr3 −/− are noted to have an altered intercellular cohesion of basal cells, epidermal hyperplasia, and modulation of genes that contribute to intercellular adhesion and cell arrangement [ 29 ]. Notably, Chmr3 −/− mice and patients with PV both display an altered epidermal morphology [ 29 ]. Most recently, our team characterized the cellular and molecular mechanisms by which M3 mAChR controls the epidermal structure and function.…”
Section: Anti-achr Autoimmunity In Pemphigusmentioning
confidence: 99%
“…M3 mAChR knockout mice ( Chmr3 −/− are noted to have an altered intercellular cohesion of basal cells, epidermal hyperplasia, and modulation of genes that contribute to intercellular adhesion and cell arrangement [ 29 ]. Notably, Chmr3 −/− mice and patients with PV both display an altered epidermal morphology [ 29 ]. Most recently, our team characterized the cellular and molecular mechanisms by which M3 mAChR controls the epidermal structure and function.…”
Section: Anti-achr Autoimmunity In Pemphigusmentioning
confidence: 99%
“…The M 3 R is one of the five muscarinic GPCRs (M1-M5) to which acetylcholine binds to initiate cellular responses (Kruse et al, 2014a). For the M 3 R, physiological responses include vasoconstriction, bronchoconstriction, insulin secretion, visual accommodation, and epidermal differentiation (Duan et al, 2022;Duttaroy et al, 2004;Kruse et al, 2014b). The M 3 R is expressed in a wide variety of tissues, including smooth muscle and pancreatic beta cells, as well as immune cells such B cells and T cells where their function is not yet clearly established (Kawashima and Fujii, 2004;Wess, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…It consists of a single exon and contains over 1100 single nucleotide polymorphisms (SNPs), making it the most polymorphic gene among the muscarinic receptors. 20 , 21 A growing body of evidence suggests that missense mutations in the CHRM3 gene are functionally associated with increased BP due to enhanced signaling and re‐sensitization of M3R. These mutations also promote the production of epinephrine.…”
Section: Introductionmentioning
confidence: 99%