The M-wave and CNV in the squirrel monkey: Generality of cue modality and of reward

Boyd, Eugene S.; Boyd, Eleanor H.; Brown, L. E.

doi:10.1016/0013-4694(80)90353-3

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…Compared with SNP, CNVs are longer fragments of variation with more significant effects on the growth traits of sheep. More and more copy number variation studies have been performed on different species, such as human [24], mouse [25], cattle [26,27], chicken [28], monkey [29], and sheep [30,31]. In recent years, with increasing consumer requirements for sheep quality and the development of molecular breeding, there is a need to exploit CNV molecular genetic variation for economic trait selection and disease prevention.…”

Section: Discussionmentioning

confidence: 99%

Copy Number Variation of the PIGY Gene in Sheep and Its Association Analysis with Growth Traits

Feng

Cheng

et al. 2020

Animals

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Simple Summary:The PIGY (phosphatidylinositol glycan anchor biosynthesis class Y) gene is a member of the PIG gene family and encodes the glycosylphosphatidylinositol-Nacetylglucosaminyltransferase (GPI-GnT) complex. It initiates the biosynthesis of GPI and plays an important role in cell-cell interactions. Sequencing has revealed a 3600 bp copy number variation (CNV) in exon 2 of the PIGY gene in sheep, potentially altering a functional part of the protein. The CNV overlaps 28 quantitative trait loci that are relevant to some economic traits like muscle density and carcass weight. We screened for this CNV of the PIGY gene in 569 individuals, namely, 240 Chaka sheep (CKS), 168 Hu sheep (HS), and 161 small-tailed Han sheep (STHS), and analyzed the association between the presence of this CNV and sheep body size traits. The results showed that the loss-type CNV was more prevalent than other types in these three breeds, and there were significant effects of the PIGY gene CNV on body weight, chest circumference, and circumference of cannon bone of sheep. The results showed that sheep with gain-type CNV had better growth traits than those with other types. The findings reveal the relationship between the CNV of the PIGY gene and growth traits of sheep, suggesting that CNV could be utilized for improved molecular breeding of sheep.Abstract: Copy number variation (CNV) is a type of genomic variation with an important effect on animal phenotype. We found that the PIGY gene contains a 3600 bp copy number variation (CNV) region located in chromosome 6 of sheep (Oar_v4.0 36,121,601-36,125,200 bp). This region overlaps with multiple quantitative trait loci related to phenotypes like muscle density and carcass weight. Therefore, in this study, the copy number variation of the PIGY gene was screened in three Chinese sheep breeds, namely, Chaka sheep (CKS, May of 2018, Wulan County, Qinghai Province, China), Hu sheep (HS, May of 2015, Mengjin County, Henan Province, China), and small-tailed Han sheep (STHS, May of 2016, Yongjing, Gansu Province, China). Association analyses were performed on the presence of CNV and sheep body size traits. We used real-time quantitative PCR (qPCR) to detect the CNV for association analysis. According to the results, the loss-type CNV was more common than other types in the three breeds (global average: loss = 61.5%, normal = 17.5%, and gain = 21.0%). The association analysis also showed significant effects of the PIGY gene CNV on body weight, chest circumference, and circumference of the cannon bone of sheep. Sheep with gain-type CNV had better growth traits than those with other types. The results indicate a clear relationship between the PIGY gene CNV and growth traits of sheep, suggesting the use of CNV as a new molecular breeding marker.

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Section: Discussionmentioning

confidence: 99%

Copy Number Variation of the PIGY Gene in Sheep and Its Association Analysis with Growth Traits

Feng

Cheng

et al. 2020

Animals

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“…The insertion mutation of lncFAM 97 bp was closely related to the growth traits of chickens at different growth stages (Li et al ., 2020). In addition, CNV has been used for breeding in sheep (Jenkins et al ., 2016; Yang et al ., 2018) and monkeys (Boyd et al ., 1980). Our study found that CNV of WBP1L gene was significantly correlated with growth traits of a variety of Chinese yellow cattle.…”

Section: Discussionmentioning

confidence: 99%

Copy number variation of WBP1L gene revealed its association with growth traits across Chinese cattle populations

Zhang

Liu³

et al. 2022

J. Agric. Sci.

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Copy number variation (CNV) is a very common type of gene variation with high frequency. In recent years, CNV has been paid more attention in various fields, especially in livestock and poultry breeding, which has promoted the progress of breeding. WW domain binding protein 1-like (WBP1L) is a protein coding gene, which plays an important role in cattle populations, and its function has been extensively studied, but it is not clear whether the copy number of the gene can affect the growth and development of cattle populations. In this study, CNV of WBP1L gene was detected in 732 cattle of seven breeds (Qinchuan cattle, QC; Pinan cattle, PN; Yuengling cattle, YL; Xianan cattle, XN; Jiaxian cattle, JX; natural Guyuan cattle, NGY; Jian cattle, JA). In addition, the relationship between CNV and growth phenotype of cattle was studied. The experimental data indicate that the copy number of WBP1L was obviously correlated with heart girth of PN cattle (**P < 0.01), rump length (RL) and body weight (BW) of PN cattle (*P < 0.05), withers height (WH), RL, body length, chest depth and BW of JX cattle (*P < 0.05), WH of NGY cattle (*P < 0.05) and WH of JA cattle (*P < 0.05). It was proved that CNV of WBP1L gene could be used as molecular marker locus for genetic breeding of the above four cattle breeds.

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Precentral cortex unit activity during the M-wave and contingent negative variation in behaving squirrel monkeys

Boyd¹,

Boyd²,

Brown³

1982

Experimental Neurology

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The M-wave and CNV in the squirrel monkey: Generality of cue modality and of reward

Cited by 9 publications

References 17 publications

Copy Number Variation of the PIGY Gene in Sheep and Its Association Analysis with Growth Traits

Copy Number Variation of the PIGY Gene in Sheep and Its Association Analysis with Growth Traits

Copy number variation of WBP1L gene revealed its association with growth traits across Chinese cattle populations

Precentral cortex unit activity during the M-wave and contingent negative variation in behaving squirrel monkeys

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