The Lungs in Rheumatoid Arthritis

Scadding, J. G.

doi:10.1177/003591576906200306

Cited by 26 publications

(20 citation statements)

References 70 publications

(57 reference statements)

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“…The widespread pulmonary fibrosis, in many instances leading to "honeycombing," that occurs in a few cases of rheumatoid arthritis generally conforms to the mural pattem of fibrosing alveolitis (Scadding, 1969). The diagnosis can be made in most of these cases with sufficient probability on be involved; and in s,ome, notably among budgerigar fanciers, an asthmatic element, involving airways, is evidently present.…”

Section: Present Seriesmentioning

confidence: 88%

Lung biopsy in the diagnosis of diffuse lung disease.

Scadding¹

1970

BMJ

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Section: Present Seriesmentioning

confidence: 88%

Lung biopsy in the diagnosis of diffuse lung disease.

Scadding¹

1970

BMJ

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“…Seronegative systemic lupus erythematosus occurs in 5 to 10% of cases (26), however, DAH usually occurs in established cases and is associated with glomerulonephritis (8,27). The follow-up period is useful in ruling out seronegative lupus erythematosus, given that pulmonary manifestations of collagen vascular disease may precede extrapulmonary manifestations by several months to years (28). None of the subjects met the revised criteria for the diagnosis of systemic lupus erythematosus (29).…”

Section: Discussionmentioning

confidence: 99%

Diffuse alveolar hemorrhage with underlying isolated, pauciimmune pulmonary capillaritis.

Jennings¹,

King²,

Tuder³

et al. 1997

Am J Respir Crit Care Med

117

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Diffuse alveolar hemorrhage (DAH) resulting from pulmonary capillaritis typically accompanies the systemic vasculitides and collagen vascular diseases. Isolated pulmonary capillaritis and DAH without systemic disease occurs in patients with antineutrophil cytoplasmic antibodies. However, isolated pulmonary capillaritis and DAH is not described for patients without clinical or serologic evidence for an underlying systemic disease. To describe such patients, we undertook a retrospective chart review of 29 patients with DAH and biopsy-proven pulmonary capillaritis from seven Denver hospitals. Eight (28%) were diagnosed with isolated pulmonary capillaritis without clinical, serologic, or histologic evidence of an associated illness. Their median age was 30 yr. No association with occupational or drug exposures was identified. All had lower respiratory tract symptoms; seven had upper respiratory tract symptoms. None demonstrated systemic disease or evidence of glomerulonephritis. All were antineutrophil cytoplasmic antibody negative. Other serologies were not significant where measured. Direct immunofluorescence studies of lung tissue were negative in five. Six presented with acute respiratory failure, four requiring mechanical ventilation. One died during initial hospitalization; seven survived. Median follow-up is 43 mo (7 to 73 mo). Five remain in remission. Two experienced multiple recurrences of DAH but without development of systemic disease while on therapy. Herein we characterize DAH and isolated pulmonary capillaritis in the absence of clinical, serologic, or histologic evidence indicating an accompanying systemic illness. The prognosis for this group appears favorable.

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“…Last year, in the Philip Ellman lecture at the Royal Society of Medicine, Scadding (1969) reviewed the whole question of lung involvement in rheumatoid arthritis. He classified such lesions as (1) nodules having a histological structure similar to that of rheumatoid arthritis ; (2) pleural effusions sometimes associated with pleural nodules or plaques ; and (3) widespread diffuse chronic inflammatory peripheral changes leading to fibrosis-that is, a fibrosing alveolitis.…”

Section: Patterns Of Lung Lesionsmentioning

confidence: 99%