The Lung Allocation Score Goes Global

Egan, Thomas M.

doi:10.1111/ajt.12754

Cited by 2 publications

(1 citation statement)

References 5 publications

(3 reference statements)

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“…Second, 13% of our PAH patients on the waitlist have approved exceptional LAS requests and/or special business rules, resulting in significantly higher LAS in Germany than in the United States . Third, the national geographic sharing of donor lungs in Germany is likely to result in comparably low waitlist mortality rates in PAH patients at our center . And fourth, the increasing use of post‐LTx ECMO support in our PAH patients might have favored post‐LTx ECMO instead of underlying PAH as an independent predictor of death.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Hadem

Gottlieb

Seifert

et al. 2016

American Journal of Transplantation

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This single-center study examines the incidence, etiology, and outcomes associated with prolonged mechanical ventilation (PMV), defined as time to definite spontaneous ventilation >21 days after double lung transplantation (LTx). A total of 690 LTx recipients between January 2005 and December 2012 were analyzed. PMV was necessary in 95 (13.8%) patients with decreasing incidence during the observation period (p < 0.001). Independent predictors of PMV were renal replacement therapy (odds ratio [OR]

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Section: Discussionmentioning

confidence: 99%

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Hadem

Gottlieb

Seifert

et al. 2016

American Journal of Transplantation

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Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation

Kim,

Shim

et al. 2023

Respir Res

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Background Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates. Although lung transplantation is a life-saving treatment for selected patients with ILD, its outcomes in those presenting with AE-ILD have yielded conflicting results compared with those with stable ILD. This study aims to investigate the impact of pre-existing AE on the prognosis of ILD patients who underwent lung transplantation. Method We conducted a single-center retrospective study by reviewing the medical records of 108 patients who underwent lung transplantation for predisposing ILD at Asan Medical Center, Seoul, South Korea, between 2008 and 2022. The primary objective was to compare the survival of patients with AE-ILD at the time of transplantation with those without AE-ILD. Results Among the 108 patients, 52 (48.1%) experienced AE-ILD at the time of lung transplantation, and 81 (75.0%) required pre-transplant mechanical ventilation. Although the type of ILD (IPF vs. non-IPF ILD) did not affect clinical outcomes after transplantation, AE-ILD was associated with worse survival outcomes. The survival probabilities at 90 days, 1 year, and 3 years post-transplant for patients with AE-ILD were 86.5%, 73.1%, and 60.1%, respectively, while those for patients without AE-ILD were higher, at 92.9%, 83.9%, and 79.6% (p = 0.032). In the multivariable analysis, pre-existing AE was an independent prognostic factor for mortality in ILD patients who underwent lung transplantation. Conclusions Although lung transplantation remains an effective treatment option for ILD patients with pre-existing AE, careful consideration is needed, especially in patients requiring pre-transplant mechanical respiratory support.

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The Lung Allocation Score Goes Global

Abstract: Gottlieb et al (page 1318) find encouraging results from Germany's use of a lung allocation score and nationwide allocation of lungs, that perhaps will prompt the Organ Procurement and Transplantation Network to diminish the roles of geography and waiting time in US organ allocation.

Cited by 2 publications

References 5 publications

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation

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