The luminescence properties of some anti-inflammatory and antipyretic drugs

Miller, James N.; Phillipps, D. L.; Burns, D. Thorburn; Bridges, James W.

doi:10.1016/0039-9140(78)80074-5

Cited by 22 publications

(2 citation statements)

References 6 publications

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“…All RTP intensities were recorded under a continuous flow of dry nitrogen to avoid possible quenching effects from oxygen and moisture. 11,12…”

Section: Methodsmentioning

confidence: 99%

“…10,11 To the extent of our knowledge, this is the first time that indomethacin phosphorescence characteristics have been studied at room temperature and that SS-RTP has been used for its determination in dosage forms. Previous studies dealing with indomethacin phosphorescence emission were performed at 77 K. 12 This methodology presents several practical disadvantages when compared with RTP procedures. 10,11…”

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confidence: 99%

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Phosphorimetric Determination of Indomethacin in Pharmaceutical Formulations

Arruda¹,

Campiglia²

1997

Analyst

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A simple, rapid and sensitive method for the determination of indomethacin was developed based on solid-surface room-temperature phosphorimetry. Phosphorescence emission was induced by the indomethacin hydrolysis reaction in a basic medium. Chromatography paper treated for background reduction was employed as a solid substrate. The use of four heavy-atom salts and sodium dodecyl sulfate was optimized to estimate an absolute limit of detection at the subnanogram level. A calibration curve with a linear dynamic range extending over two orders of magnitude (3.0 x 10(-7)-1.0 x 10(-4) mol dm-3) was obtained. The recovery of the method (98.4 +/- 6.8%) was tested using commercial formulations containing indomethacin as the only anti-inflammatory agent.

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“…All RTP intensities were recorded under a continuous flow of dry nitrogen to avoid possible quenching effects from oxygen and moisture. 11,12…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%