The luminal connection

Kao, Robert M.

doi:10.4161/org.25225

Cited by 9 publications

(4 citation statements)

References 54 publications

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“…The openings on each structure will then allow for fusion/joining. There are other potential mechanisms by which tubes connect as has been shown in Xenopus laevis , Drosophila melanogaster , Danio rerio, and Caenorhabditis elegans (see review by Kao, ). For example, as the tubes approach each other, there is considerable modification of the tight junctions within the epithelial cells resulting in a transitional mesenchymal type of cell that allows for invasion between the most distal ends of the tubes.…”

Section: ‘Connect With Me’ Says the Rete Testis To The Efferent Ductsmentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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Background:The mechanisms by which the rete testis joins the efferent ducts, which joins the Wolffian duct during development, are not known. Mouse and chick models have been helpful in identifying genes that are important for the development of each part, but genes have not been identified as to those that play a role in the joining of each part. Clinical implications of the failure of the male reproductive tract to form a fully functional conduit for spermatozoa are not trivial. Epididymal disjunction, the failure of the efferent ducts to join the testis, is one of several epididymal anomalies that have been observed in some boys who were cryptorchid at birth. Objective: A systematic review of studies focusing on the morphogenesis of the mesonephric duct and mesonephric tubules in different species, and identification of clinical issues should there be failure of these tissues to develop. Design: PubMed and GUDMAP databases, and review of books on kidney development were searched for studies reporting on the mechanisms of morphogenesis of the kidney and epididymis. Main outcomes measure(s): Gaps in our knowledge were identified, and hypotheses coupled with suggestions for future experiments were presented. Results: A total of 64 papers were identified as relevant, of which 53 were original research articles and 11 were book chapters and reviews covering morphogenesis and clinical issues. Investigators utilized multiple species including, human, mouse, chick, Xenopus, bovine, and sheep. Conclusion: Fundamental understanding of the morphogenesis of the male reproductive tract is limited, especially the morphogenesis of the rete testis and efferent ducts. Therefore, it is not surprising that we do not understand how each part unites to form a whole. Only one mechanism of joining of one part of the tract to another was identified: the joining of the Wolffian duct to the cloaca via controlled apoptosis.

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Section: ‘Connect With Me’ Says the Rete Testis To The Efferent Ductsmentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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“…The juxtaposed parenchymal and endothelial BMs specifically link within the capillaries of the central nervous system, but are separated by a perivascular space at the post-capillary venules (Fig. 5B) [15, 76, 79, 80]. The BM-BM-linked capillary region of the BBB has unique properties as it is the site of nutrient transport, and is also a location that specifically excludes T-cell trafficking [15, 76].…”

Section: Long-term Bm-bm Adhesions In Organ Structure and Filtrationmentioning

confidence: 99%

Tissue linkage through adjoining basement membranes: The long and the short term of it

Keeley

Sherwood

2019

Matrix Biology

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Basement membranes (BMs) are thin dense sheets of extracellular matrix that surround most tissues. When the BMs of neighboring tissues come into contact, they usually slide along one another and act to separate tissues and organs into distinct compartments. However, in certain specialized regions, the BMs of neighboring tissues link, helping to bring tissues together. These BM connections can be transient, such as during tissue fusion events in development, or long-term, as with adult tissues involved with filtration, including the blood brain barrier and kidney glomerulus. The transitory nature of these connections in development and the complexity of tissue filtration systems in adults have hindered the understanding of how juxtaposed BMs fasten together. The recent identification of a BM-BM adhesion system in C. elegans, termed B-LINK (BM linkage), however, is revealing cellular and extracellular matrix components of a nascent tissue adhesion system. We discuss insights gained from studying the B-LINK tissue adhesion system in C. elegans, compare this adhesion with other BM-BM connections in Drosophila and vertebrates, and outline important future directions towards elucidating this fascinating and poorly understood mode of adhesion that joins neighboring tissues.

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“…In addition, the process of wound healing in the skin and other organs involves first a stage in which epithelial cells lose their epithelial properties and spread to cover the wound, followed by a stage of re-epithelialization to restore the epithelial barrier of the wounded tissue 11,12 . Defects in MET are implicated in a number of pathologies, including kidney malformation and lumenopathies 2,13 .…”

Section: Introductionmentioning

confidence: 99%

A Morphogenetic Wave that Generates Mesenchymal-to-Epithelial Transition in the Lateral Plate Mesoderm

Asleh

Zaher

Jadon

et al. 2022

Preprint

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Most mesodermal cells undergo multiple cycles of transition between an epithelial and mesenchymal state during embryonic development. While many studies have addressed the process of epithelial-to-mesenchymal transition (EMT), comparatively less is known regarding the complementary process, mesenchymal-to-epithelial transition (MET), which is essential for organogenesis and has also been proposed to be important for cancer metastasis. The current study investigated MET using the lateral plate mesoderm (LPM) of the chick embryo as a model system. We find that MET in the LPM proceeds as a wave, which divides the LPM into distinct mesenchymal, transition, and epithelial zones. In the multilayered mesenchymal zone, many apical epithelial markers, including N-Cadherin (N-Cad), Par-3 and Zo-1, but not atypical protein kinase C (aPKC), are detected as dispersed, partially co-localizing aggregates associated with cell-cell contacts. The transition zone is characterized by the appearance of aPKC and the formation of rosette-like structures characterized by wedge-shaped cells that are apical-basal polarized, with strong co-localization of apical polarity markers, but not yet arranged into distinct epithelial sheets. The transition zone is also enriched in mitotic cells. Subsequently, the rosettes resolve into two well-defined epithelial sheets that constitute the coelomic epithelium, the lining of the internal body cavity. Prior to any overt signs of apical-basal polarity, fibronectin (FN) begins to accumulate at the future basal side of the incipient epithelium. Interference with Extracellular Matrix (ECM)-integrin signaling through disruption of focal adhesion kinase (FAK) or Talin function hindered the normal progression of the epithelialization process. Cells with disrupted FAK or Talin function retained mesenchymal-like characteristics with respect to cellular morphology and apical-basal marker distribution. We propose a two-stage process for MET in the LPM. Initially, in the polarization phase, ECM-integrin-dependent signaling imparts apical-basal polarity, culminating in the activation of aPKC, to drive cell intercalation and rosette formation. Subsequently in the resolution phase, polarized rosette cells, perhaps facilitated by the weakening of cell-cell interactions that occurs during mitosis, expand their apical surface, and spread out to form new connections laterally to their fully epithelial neighbors. This sequence of events is propagated as a wave through the LPM, thus generating an integrated coelomic epithelium.

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The luminal connection

Cited by 9 publications

References 54 publications

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Tissue linkage through adjoining basement membranes: The long and the short term of it

A Morphogenetic Wave that Generates Mesenchymal-to-Epithelial Transition in the Lateral Plate Mesoderm

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