The <i>in vivo</i> Antibradykinin Activity of Seclazone (7-Chloro-3,3a-Dihydro-2H,9H-Isoxazolo[3,2-b] [1,3]Benzoxazin-9-One), a New Anti-Inflammatory Agent

Abstract

Seclazone, a new antipyretic and anti-inflammatory compound with diuretic properties significantly inhibits the bradykinin-induced bronchoconstrictor responses of guinea-pig lungs in vivo without altering those produced by histamine. Pretreatment with seclazone (150 or 300 mg/kg, p.o.) also preventsthe increases in vascular permeability of rat skin after intradermal injection of bradykinin.

Antagonism by Meseclazone and Other Nonsteroidal Anti-Inflammatory Drugs of Bradykinin-Induced Bronchospasm

“…The results indicate that meseclazone, like the other NSAIDs tested, did exhibit a dosedependent inhibition of bradykinin-induced bronchospasm in the guinea pig similar to that reported for the nor-methyl parent com pound, seclazone [Hrdina and Ling, 1973). However, unlike the in vitro results on tra cheal tone in which it was about four times more potent than aspirin [Diamonds et al, 1979], the in vivo activity was markedly less potent than aspirin (table I).…”