The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study

Asperti, André Marangoni; Junior, Paulo Martins Reis; Diniz, Márcio A.; Pinto, M.D.P.; Júnior, Edinésio Carlos da Silva; Silva, Danilo Felipe Dias da; D’Albuquerque, Luiz Augusto Carneiro; Andraus, Wellington

doi:10.6061/clinics/2016(07)02

Cited by 3 publications

(3 citation statements)

References 26 publications

(62 reference statements)

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“…Chile is the country with the highest prevalence of gallstones in the world with a global incidence of 30%: 45% in women and 25% in men over 20 years of age [8,15] . In Mexico, the prevalence of cholelithiasis in the general population is 14.3%…”

Section: Epidemiologymentioning

confidence: 99%

Clinical Manifestations of Cholelithiasis in Quito, Ecuador. A Cohort Study

Mario¹,

Mayra²,

Luis³

2021

ajsrr

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Introduction: A prospective study was carried out, with the aim of establishing the clinical manifestations of cholelithiasis in the population of Quito, Ecuador. Methods: During the period from January 2012 to October 2017, 534 patients were referred from different outpatient clinics of the Ecuadorian Institute of Social Security to the Batan Medical Center with the diagnosis of cholelithiasis after a clinical assessment and abdominal ultrasound, to be treated surgically. Results: Sixty-nine percent of patients were female with a male-female ratio of 1:2.21. Mean age was 44.9 years. Pain was the most common symptom in our study: 95.7%. Among these patients, pain was located in the epigastrium in 49.8%, in the right hypochondrium in 45.1% and only 0.8% had low back pain. Pain ranged from moderate and even severe. The remaining 4.3% of patients had dyspepsia or were asymptomatic. Conclusions: This finding highlights the fact that epigastric pain must be always considered as a clinical manifestation on cholelithiasis.

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Section: Epidemiologymentioning

confidence: 99%

Clinical Manifestations of Cholelithiasis in Quito, Ecuador. A Cohort Study

Mario¹,

Mayra²,

Luis³

2021

ajsrr

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“…Gallbladder disease (GBD) is one of the most common gastrointestinal disorders and the leading causes of hospital admissions and surgery worldwide, responsible for over 700,000 cholecystectomies per year in the United States 4 , 19 , 25 . Global prevalence varies from 3% to 47%, with an estimated risk of 7.9% in men and 16.6% in women 4 , 25 , 29 . In Brazil, GBD affects about 10% of the general population, being accountable for over 185,000 cholecystectomies yearly 6 , 9 .…”

Section: Introductionmentioning

confidence: 99%

“…In Western countries, the disease is mainly caused by cholesterol stone formation (>85%), and approximately 95% of cases of cholecystitis are the result of obstructive lithogenesis 4 , 13 . Pathogenesis of gallstone disease is considered multifactorial and results from a complex interaction between genetic, hormonal, physiological, behavioral, and environmental factors 10 , 27 , 29 .…”

Section: Introductionmentioning

confidence: 99%

A Population Study on Gender and Ethnicity Differences in Gallbladder Disease in Brazil

Nascimento

Tomaz

Souza-Filho

et al. 2022

ABCD, arq. bras. cir. dig.

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- BACKGROUND: Gallbladder diseases (GBD) are one of the most common medical conditions requiring surgical intervention, both electively and urgently. It is widely accepted that sex and ethnic characteristics mighty influence both prevalence and outcomes. AIM: This study aimed to evaluate the differences on distributions of gender and ethnicity related to the epidemiology of GBD in the Brazilian public health system. METHODS: DATASUS was used to retrieve patients’ data recorded under the International Code of Diseases (ICD-10) - code K80 from January 2008 to December 2019. The number of admissions, modality of care, number of deaths, and in-hospital mortality rate were analyzed by gender and ethnic groups. RESULTS: Between 2008 and 2019, a total of 2,899,712 patients with cholelithiasis/cholecystitis (K80) were admitted to the hospitals of the Brazilian Unified Health System, of whom only 22.7% were males. Yet, the in-hospital mortality rate was significantly higher in males (15.9 per 1,000 male patients) than females (6.3 per 1,000 female patients) (p<0.05). Moreover, men presented a significantly higher risk of death (RR=2.5; p<0.05) and longer hospital stay (4.4 days vs. 3.3 days; p<0.05) than females. Compared to females, men presented a higher risk of death across all self-declared ethnic groups: whites (RR=2.4; p<0.05), blacks (RR=2.7; p<0.05), browns (RR=2.6; p<0.05), and Brazilian Indians (RR=2.13; p<0.05). CONCLUSION: In the years 2008-2019, women presented the highest prevalence of hospital admissions for GBD in Brazil, and men were associated with worse outcomes, including all ethnic groups.

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Gallbladder and extrahepatic bile duct cancers in the Americas: Incidence and mortality patterns and trends

Miranda‐Filho

Piñeros

Ferreccio

et al. 2020

Intl Journal of Cancer

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Trends in gallbladder cancer incidence and mortality in populations across the Americas can provide insight into shifting epidemiologic patterns and the current and potential impact of preventative and curative programs. Estimates of gallbladder and extrahepatic bile duct cancer incidence and mortality for the year 2018 were extracted from International Agency for Research on Cancer (IARC) GLOBOCAN database for 185 countries. Recorded registry‐based incidence from 13 countries was extracted from IARCs Cancer Incidence in Five Continents series and corresponding national deaths from the WHO mortality database. Among females, the highest estimated incidence for gallbladder and extrahepatic bile duct cancer in the Americas were found in Bolivia (21.0 per 100,000), Chile (11.7) and Peru (6.0). In the US, the highest incidence rates were observed among Hispanics (1.8). In the Chilean population, gallbladder cancer rates declined in both females and males between 1998 and 2012. Rates dropped slightly in Canada, Costa Rica, US Whites and Hispanics in Los Angeles. Gallbladder cancer mortality rates also decreased across the studied countries, although rising trends were observed in Colombia and Canada after 2010. Countries within Southern and Central America tended to have a higher proportion of unspecified biliary tract cancers. In public health terms, the decline in gallbladder cancer incidence and mortality rates is encouraging. However, the slight increase in mortality rates during recent years in Colombia and Canada warrant further attention. Higher proportions of unspecified biliary tract cancers (with correspondingly higher mortality rates) suggest more rigorous pathology procedures may be needed after surgery.

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The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study

Cited by 3 publications

References 26 publications

Clinical Manifestations of Cholelithiasis in Quito, Ecuador. A Cohort Study

Clinical Manifestations of Cholelithiasis in Quito, Ecuador. A Cohort Study

A Population Study on Gender and Ethnicity Differences in Gallbladder Disease in Brazil

Gallbladder and extrahepatic bile duct cancers in the Americas: Incidence and mortality patterns and trends

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