The lower airway microbiota in infants with severe bronchiolitis is largely similar to the upper airway microbiota

Mulholland, Anna; Broderick, David; Missen, Sarah; Fontaine, Tom; Radcliff, Fiona J.; Beca, John; Taylor, Mike; Pillarisetti, Naveen

doi:10.1183/13993003.congress-2019.pa4992

Cited by 2 publications

(3 citation statements)

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“…Regional and age-specific differences in respiratory flora may limit generalisability of our results to infants in low- and middle-income countries or different age groups (e.g., older adults). In addition, the observed profile of co-detected upper respiratory pathogens may not directly reflect the lower airway profile; however, some studies suggest a similarity between the upper and lower airway microbiota 48 , 49 . Although our method covers a comprehensive list of viruses, co-detection does not imply capacity to initiate infection in the absence of RSV.…”

Section: Discussionmentioning

confidence: 96%

Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus

Lin,

Drysdale,

Snape

et al. 2024

Nat Commun

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Respiratory syncytial virus (RSV) is the leading cause of hospitalisation for respiratory infection in young children. RSV disease severity is known to be age-dependent and highest in young infants, but other correlates of severity, particularly the presence of additional respiratory pathogens, are less well understood. In this study, nasopharyngeal swabs were collected from two cohorts of RSV-positive infants <12 months in Spain, the UK, and the Netherlands during 2017–20. We show, using targeted metagenomic sequencing of >100 pathogens, including all common respiratory viruses and bacteria, from samples collected from 433 infants, that burden of additional viruses is common (111/433, 26%) but only modestly correlates with RSV disease severity. In contrast, there is strong evidence in both cohorts and across age groups that presence of Haemophilus bacteria (194/433, 45%) is associated with higher severity, including much higher rates of hospitalisation (odds ratio 4.25, 95% CI 2.03–9.31). There is no evidence for association between higher severity and other detected bacteria, and no difference in severity between RSV genotypes. Our findings reveal the genomic diversity of additional pathogens during RSV infection in infants, and provide an evidence base for future causal investigations of the impact of co-infection on RSV disease severity.

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Section: Discussionmentioning

confidence: 96%

Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus

Lin,

Drysdale,

Snape

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Bronchiolitis and microbiota was one of the most discussed topic. The abstract by MULHOLLAND et al [39] demonstrated that, in infants hospitalised in paediatric intensive care units for bronchiolitis, the upper airway microbiota was similar to the lower airway microbiota. PERSIA et al [40] demonstrated that in respiratory syncytial virus (RSV) bronchiolitis the nasopharyngeal microbiota have a reduced alfa-diversity compared to virus negative infants with bronchiolitis.…”

Section: Paediatric Respiratory Infection and Immunologymentioning

confidence: 99%

“…The abstract by M ulholland et al . [ 39 ] demonstrated that, in infants hospitalised in paediatric intensive care units for bronchiolitis, the upper airway microbiota was similar to the lower airway microbiota. P ersia et al .…”

Section: Paediatric Respiratory Infection and Immunologymentioning

confidence: 99%

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

et al. 2020

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The lower airway microbiota in infants with severe bronchiolitis is largely similar to the upper airway microbiota

Cited by 2 publications

References 0 publications

Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus

Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

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