The low-energy β− and electron emitter 161Tb as an alternative to 177Lu for targeted radionuclide therapy

Dose Deposits from 90Y, 177Lu, 111In, and 161Tb in Micrometastases of Various Sizes: Implications for Radiopharmaceutical Therapy

“…Moreover, 2 isotopes of terbium ( 152 Tb: half-life, 17.5 h, b 1 emitter; and 155 Tb: half-life, 5.32 d, g-emitter) offer the possibility for pretherapy imaging and dosimetry with PET or SPECT. 161 Tb can be produced as no-carrier-added in large amounts, using, for example, a 160 Gd target ( 160 Gd(n,g) 161 Tb), and with good radionuclide purity ( 160 Tb-to-161 Tb activity ratio , 0.0001) (38). The cost for large-scale production was estimated to be comparable to that of no-carrier-added 177 Lu (38).…”

Radiochemical Separation of ¹⁶¹Tb from Gd/Tb Matrix Using Ln Resin Column

“…(1) Beside that, when natural Gd is irradiated, other (n,γ) nuclear reactions are also taking place leading to the formation of the other radiolanthanides as radionuclidic impurities (as seen in Table 1) and they have to be isolated from 161 Tb chemically [7,16]. The separation of two neighboring lanthanides is, however, challenging because of their high chemical similarity.…”

“…The killing of cancer cells is achieved using biological vectors and appropriate radionuclides [4][5][6]. Antibodies and antibody fragments as well as peptides are used as tracer molecules [5,7]. While, the radioisotopes are particle emitter that are able to deposit a high amount of energy in small volume via a high linear energy transfer (LET) [8,9].…”

Chelating agents for radiolanthanides: Applications to imaging and therapy

“…Below we highlight some recent examples that exploit the use of peptide functionalised ligands for radiolanthanides for imaging and therapeutic purposes. Amongst the other radiolanthanides, Zhernosekov 19 has reported the synthesis and purification of 161 Tb-DOTATATE with the 161 Tb obtained from isotopically enriched 160 Gd. The synthesis of 161 Tb-DOTATATE was reported using a 1:12 metal:ligand ratio with >99% yield at pH 4.5-5 (100°C, 0.5 h); in comparison, 177 Lu may be more efficiently used at a 1:4 ratio.…”