The low anterior resection syndrome in a reference population: prevalence and predictive factors in the Netherlands

Heinsbergen, Maarten van; Heijden, J. Van Der; Stassen, Laurents P. S.; Melenhorst, Jarno; Witte, Evelien de; Belgers, E.; Maaskant‐Braat, A. J. G.; Bloemen, Johanne G.; Bouvy, Nicole D.; Janssen‐Heijnen, M.L.G.; Konsten, J.

doi:10.1111/codi.14790

Cited by 36 publications

(38 citation statements)

References 26 publications

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“…The aetiology of LARS is yet not entirely understood [8] and there are recent data indicating that LARS-like symptoms are present in the general population [9][10][11]. This emphasizes the importance of reflecting on the relationship between bother (subjective, symptom-associated distress) and LARS score, as we only need to evaluate and treat symptoms that create an impact or affect a patient's QoL.…”

Section: Introductionmentioning

confidence: 99%

Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow‐up within the QoLiRECT study

et al. 2020

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Aim Low anterior resection syndrome (LARS) is common after low anterior resection. Our aim was to evaluate the prevalence and 'bother' (subjective, symptomassociated distress) of major LARS after 1 and 2 years, identify possible risk factors and relate the bowel function to a reference population. Method The QoLiRECT (Quality of Life in RECTal cancer) study is a Scandinavian prospective multicentre study including 1248 patients with rectal cancer, of whom 552 had an anterior resection. Patient questionnaires were distributed at diagnosis and after 1, 2 and 5 years. Data from the baseline and at 1-and 2-year follow-up were included in this study. Results The LARS score was calculated for 309 patients at 1 year and 334 patients at 2 years. Prevalence was assessed by a generalized linear mixed effects model. Major LARS was found in 63% at 1 year and 56% at 2 years. Bother was evident in 55% at 1 year, decreasing to 46% at 2 years. Major LARS was most common among younger women (69%). Among younger patients, only marginal improvement was seen over time (63-59%), for older patients there was more improvement (62-52%). In the reference population, the highest prevalence of major LARSlike symptoms was noted in older women (12%). Preoperative radiotherapy, defunctioning stoma and tumour height were found to be associated with major LARS. Conclusion Major LARS is common and possibly persistent over time. Younger patients, especially women, are more affected, and perhaps these patients should be prioritized for early stoma closure to improve the chance of a more normal bowel function.

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Section: Introductionmentioning

confidence: 99%

Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow‐up within the QoLiRECT study

et al. 2020

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“…Opposingly, previous studies perceived female patients aged 50 to 79 to have a higher proportion of Major LARS and worse functional outcome while age remains a subject of controversy between studies correlating young age to worse LARS scores and those not finding a significant correlation. (21)(22)(23)(24) Our study has some limitations such as the retrospective observational aspect when selecting the patients. Taking the high level of illiteracy, it was not possible for the patients to complete the questionnaire solely but either with the help of an interviewer who was reading the questions or through phone communications.…”

Section: Discussionmentioning

confidence: 99%

Validation of the arabic version of the low anterior resection syndrome score

Essangri

Majbar²,

Benkabbou

et al. 2020

Preprint

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Purpose: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research. Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria. Results: The arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, Chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.

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“…Opposingly, previous studies perceived female patients aged 50 to 79 to have a higher proportion of Major LARS and worse functional outcome, while age remains a subject of controversy between studies correlating young age to worse LARS scores and those not nding a signi cant correlation. [27][28][29][30] Postoperative bowel dysfunction is a major health issue and its burden on patients quality of life is sometimes underestimated [31]. In Arabic communities, such manifestations may also have a strong cultural component which not only increases the quality of life impediment [32], but also represents a hurdle to adequate care due to shame and miscommunication.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Moroccan arabic version of the low anterior resection syndrome score

Essangri¹,

Majbar²,

Benkabbou³

et al. 2020

Preprint

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Background: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this observational study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research.Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment, while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria.Results: The Moroccan Arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Moroccan Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.

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The low anterior resection syndrome in a reference population: prevalence and predictive factors in the Netherlands

Cited by 36 publications

References 26 publications

Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow‐up within the QoLiRECT study

Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow‐up within the QoLiRECT study

Validation of the arabic version of the low anterior resection syndrome score

Validation of the Moroccan arabic version of the low anterior resection syndrome score

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